ID A0A087X0K8_HUMAN Unreviewed; 2367 AA.
AC A0A087X0K8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 10-MAY-2017, entry version 19.
DE SubName: Full=Probable G-protein-coupled receptor 179 {ECO:0000313|Ensembl:ENSP00000483469};
GN Name=GPR179 {ECO:0000313|Ensembl:ENSP00000483469};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000483469, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000483469, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT the human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000483469}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2014) to UniProtKB.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data. {ECO:0000313|Ensembl:ENSP00000483469}.
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DR EMBL; AC244092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001004334.3; NM_001004334.3.
DR UniGene; Hs.462915; -.
DR ProteinModelPortal; A0A087X0K8; -.
DR STRING; 9606.ENSP00000345060; -.
DR PaxDb; A0A087X0K8; -.
DR PeptideAtlas; A0A087X0K8; -.
DR PRIDE; A0A087X0K8; -.
DR Ensembl; ENST00000616987; ENSP00000483469; ENSG00000277399.
DR GeneID; 440435; -.
DR KEGG; hsa:440435; -.
DR UCSC; uc002hpz.3; human.
DR CTD; 440435; -.
DR HGNC; HGNC:31371; GPR179.
DR OpenTargets; ENSG00000277399; -.
DR eggNOG; KOG4418; Eukaryota.
DR eggNOG; ENOG410XXEC; LUCA.
DR GeneTree; ENSGT00390000010934; -.
DR GenomeRNAi; 440435; -.
DR Proteomes; UP000005640; Chromosome 17.
DR ExpressionAtlas; A0A087X0K8; baseline and differential.
DR GO; GO:0044292; C:dendrite terminus; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:InterPro.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR032964; GPR179.
DR PANTHER; PTHR32546:SF20; PTHR32546:SF20; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW Membrane {ECO:0000256|SAAS:SAAS00500858, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAAS:SAAS00500858,
KW ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAAS:SAAS00500858,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}.
FT CHAIN 26 2367 {ECO:0000256|SAM:SignalP}.
FT /FTId=PRO_5001832113.
FT TRANSMEM 378 403 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 415 438 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 450 469 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 490 513 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 544 564 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 606 628 Helical. {ECO:0000256|SAM:Phobius}.
FT DOMAIN 380 650 G_PROTEIN_RECEP_F3_4.
FT {ECO:0000259|PROSITE:PS50259}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 394 632 ipfam:7tm_3 [T]
FT MYHIT 380 650 iprf:G_PROTEIN_RECEP_F3_4 [T]
SQ SEQUENCE 2367 AA; 257344 MW; F12BDEA0C746A2F2 CRC64;
MGTRGAVMPP PMWGLLGCCF VCAWALGGPR PIRSLPPLSS QVKPGSVPMQ VPLEGAEAAL
AYLYSGDAQQ LSQVNCSERY EARGAGAMPG LPPSLQGAAG TLAQAANFLN MLLQANDIRE
SSVEEDVEWY QALVRSVAEG DPRVYRALLT FNPPPGASHL QLALQATRTG EETILQDLSG
NWVQEENPPG DLDTPALKKR VLTNDLGSLG SPKWPQADGY VGDTQQVRLS PPFLECQEGR
LRPGWLITLS ATFYGLKPDL SPEVRGQVQM DVDLQSVDIN QCASGPGWYS NTHLCDLNST
QCVPLESQGF VLGRYLCRCR PGFYGASPSG GLEESDFQTT GQFGFPEGRS GRLLQCLPCP
EGCTSCMDAT PCLVEEAAVL RAAVLACQAC CMLAIFLSML VSYRCRRNKR IWASGVVLLE
TVLFGFLLLY FPVFILYFKP SVFRCIALRW VRLLGFAIVY GTIILKLYRV LQLFLSRTAQ
RSALLSSGRL LRHLGLLLLP VLGFLAVWTV GALERGIQHA PLVIRGHTPS GRHFYLCHHD
RWDYIMVVAE LLLLCWGSFL CYATRAVLSA FHEPRYMGIA LHNELLLSAA FHTARFVLVP
SLHPDWTLLL FFFHTHSTVT TTLALIFIPK FWKLGAPPRE EMVDEVCEDE LDLQHSGSYL
GSSIASAWSE HSLDPGDIRD ELKKLYAQLE VHKTKEMAAN NPHLPKKRGS SCQGLGRSFM
RYLAEFPEAL ARQHSRDSGS PGHGSLPGSS RRRLLSSSLQ EPEGTPALHK SRSTYDQRRE
QDPPLLDSLL RRKLAKKASR TESRESVEGP PALGFRSASA HNLTVGERLP RARPASLQKS
LSVASSREKA LLMASQAYLE ETYRQAKERE ERKKAKAAMA SLVRRPSARR LERPRGAPLS
APPSPAKSSS VDSSHTSGRL HEEARRRLPH PPIRHQVSTP ILALSGGLGE PRMLSPTSTL
APALLPALAP TPAPALAPVP VSPQSPNLLT YICPWENAEL PAKQENVPQE GPSGPERGHH
SPAPARARLW RALSVAVEKS RAGENEMDAE DAHHQREAND VDEDRPKIFP KSHSLKAPVQ
QGSMRSLGLA IKALTRSRST YREKESVEES PEGQNSGTAG ESMGAPSRSP RLGRPKAVSK
QAALIPSDDK ESLQNQQNAH TSRMLQVCQR EGSREQEDRG RRMTQGLGER KAERAGKTGL
AMLRQVSRDK NIKQSKETPV GWQELPKAGL QSLGSADHRV AEVCPWEVTE SETRQPDSGN
KAEICPWETS EGAPESRALR QDPGDSQKKR GEARGKSEPI DVVPMMRKKP ERLVREQEAV
CPWESADRGG LSPGSAPQDP GRIRDKSEAG DSVEARKVEK PGWEAAGPEA HTPDITKAEP
CPWEASEGGE DGKPAQEAVK DLPQEKQKTR KATFWKEQKP GGDLESLCPW ESTDFRGPSA
VSIQAPGSSE CSGSLGSGIA EVCLWEAGDA PAIQKAEICP WELDDNVMGQ EMLSLGTGRE
SLQEKEKASR KGSFGEMGEQ TVKAVQKLSQ QQESVCPRES TVPGHSSPCL DNSSSKAGSQ
FLCNGGSRAT QVCPQEDLRP EAQEATPAKT EICPWEVNER TREEWTSAQV PRGGESQKDK
EKMPGKSEIE DVTAWEKPEG QIQKQEAVGP WESVDPGSFS PQPRPQDTER PQTLLQMSGS
VGSKAADICP LDVEENLTAG KAEICPWEVG AGAGEERALG AEAIRKSPND TGKVSADLGP
RERAVTAPEK PQKPTPEWEV ACPWGSVGPG ACSQHPGTLD ADGPKAGFQE LDHMGCRPGE
VCPWEAQEAA TSEKAKICPW EVSEGTTGKG LDQKAGSESA EQREKALEKG RLTSLGEDVS
KGMAKLCQQQ ETICIWENKD LRESPAQAPK ISDLPSSMSS EVAEGHSLEA TEKGDLRQDP
KTGSFPEHIT QEKAPAADTE EFTTEDGEKT SHELQSVCPW ETTAPADSVS HLDRQRPDQP
KASSQRLVST GGRAADVCPW DVPDAGVYKS DSSAKAETCP WEVTERIPVK GVSRQDGKGD
SQEEKGRAPE KSEPKGVPVQ KKPEMADFRQ QEAVCPWESQ DGKGLSPQPA PDASDRSRGS
SEAAGSVETR VAEVCLWEVV EAPSAKKAEI CPWEAGGGAA EEGEQERESQ GQGEMFLQKA
GPGGTEEHFS KAAAKPREQE AVCPGEGTGS GGLLPQSGAL DPELKVSPKE AGSMGSRMAE
LCQWEITDPE GNKIKGTMAD ICPGEETGVP SEESGLLALT ATRREFFPTA PEKPLCLLVH
GPLDHFFPES KIPCPKVSRP ASTFTLEGVR ELQGPSGLEP RTSLAPEPSL QEAESQSSSL
TEDSGQVAFE AQYEEFTPPT VYPWDWE
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