ID A0A087WZQ2_HUMAN Unreviewed; 640 AA.
AC A0A087WZQ2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 10-MAY-2017, entry version 21.
DE SubName: Full=Zinc finger protein 343 {ECO:0000313|Ensembl:ENSP00000482819};
GN Name=ZNF343 {ECO:0000313|Ensembl:ENSP00000482819};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482819, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000482819, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [2] {ECO:0000313|Ensembl:ENSP00000482819}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2014) to UniProtKB.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data. {ECO:0000313|Ensembl:ENSP00000482819}.
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DR EMBL; AL049650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL049712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL133339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001269426.1; NM_001282497.1.
DR RefSeq; NP_001308730.1; NM_001321801.1.
DR UniGene; Hs.516846; -.
DR ProteinModelPortal; A0A087WZQ2; -.
DR PeptideAtlas; A0A087WZQ2; -.
DR PRIDE; A0A087WZQ2; -.
DR Ensembl; ENST00000612935; ENSP00000482819; ENSG00000088876.
DR GeneID; 79175; -.
DR UCSC; uc061vak.1; human.
DR CTD; 79175; -.
DR HGNC; HGNC:16017; ZNF343.
DR OpenTargets; ENSG00000088876; -.
DR GeneTree; ENSGT00530000063157; -.
DR OMA; KPEIYTC; -.
DR OrthoDB; EOG091G02KC; -.
DR GenomeRNAi; 79175; -.
DR Proteomes; UP000005640; Chromosome 20.
DR ExpressionAtlas; A0A087WZQ2; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 4: Predicted;
KW Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW Metal-binding {ECO:0000256|SAAS:SAAS00780264};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|SAAS:SAAS00780289};
KW Zinc {ECO:0000256|SAAS:SAAS00780264};
KW Zinc-finger {ECO:0000256|SAAS:SAAS00780264}.
FT DOMAIN 62 145 KRAB. {ECO:0000259|PROSITE:PS50805}.
FT DOMAIN 310 337 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 338 365 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 366 393 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 394 421 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 422 449 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 450 477 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 478 505 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 506 533 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 534 561 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 562 589 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 590 617 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 618 640 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 450 472 ismart:ZnF_C2H2 [T]
FT MYHIT 394 416 ismart:ZnF_C2H2 [T]
FT MYHIT 562 584 ismart:ZnF_C2H2 [T]
FT MYHIT 534 561 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 478 505 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 590 612 ismart:ZnF_C2H2 [T]
FT MYHIT 340 360 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 62 114 ismart:KRAB [T]
FT MYHIT 534 556 ismart:ZnF_C2H2 [T]
FT MYHIT 310 337 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 590 617 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 506 528 ismart:ZnF_C2H2 [T]
FT MYHIT 366 388 ismart:ZnF_C2H2 [T]
FT MYHIT 562 589 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 618 640 ismart:ZnF_C2H2 [T]
FT MYHIT 452 472 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 61 102 ipfam:KRAB [T]
FT MYHIT 338 360 ismart:ZnF_C2H2 [T]
FT MYHIT 366 393 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 422 444 ismart:ZnF_C2H2 [T]
FT MYHIT 592 612 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 424 444 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 62 145 iprf:KRAB [T]
FT MYHIT 394 421 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 618 640 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 508 528 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 368 388 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 312 332 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 478 500 ismart:ZnF_C2H2 [T]
FT MYHIT 396 416 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 506 533 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 310 332 ismart:ZnF_C2H2 [T]
FT MYHIT 536 556 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 338 365 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 480 500 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 564 584 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 620 640 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 422 449 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 450 477 iprf:ZINC_FINGER_C2H2_2 [T]
SQ SEQUENCE 640 AA; 73430 MW; 42B2ED37CADE21D3 CRC64;
MMLPYPSALG DQYWEEILLP KNGENVETMK KLTQNHKAKG LPSNDTDCPQ KKEGKAQIVV
PVTFRDVTVI FTEAEWKRLS PEQRNLYKEV MLENYRNLLS LDGVSLLLPR LECNRAISAH
HNLCLPGSSN SPATASRVVG ITAEPKPEIY TCSSCLLAFS CQQFLSQHVL QIFLGLCAEN
HFHPGNSSPG HWKQQGQQYS HVSCWFENAE GQERGGGSKP WSARTEERET SRAFPSPLQR
QSASPRKGNM VVETEPSSAQ RPNPVQLDKG LKELETLRFG AINCREYEPD HNLESNFITN
PRTLLGKKPY ICSDCGRSFK DRSTLIRHHR IHSMEKPYVC SECGRGFSQK SNLSRHQRTH
SEEKPYLCRE CGQSFRSKSI LNRHQWTHSE EKPYVCSECG RGFSEKSSFI RHQRTHSGEK
PYVCLECGRS FCDKSTLRKH QRIHSGEKPY VCRECGRGFS QNSDLIKHQR THLDEKPYVC
RECGRGFCDK STLIIHERTH SGEKPYVCGE CGRGFSRKSL LLVHQRTHSG EKHYVCRECR
RGFSQKSNLI RHQRTHSNEK PYICRECGRG FCDKSTLIVH ERTHSGEKPY VCSECGRGFS
RKSLLLVHQR THSGEKHYVC RECGRGFSHK SNLIRHQRTH
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