ID YQAB_ECOLI Reviewed; 188 AA.
AC P77475;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-NOV-2009, entry version 71.
DE RecName: Full=Phosphatase yqaB;
DE EC=3.1.3.-;
GN Name=yqaB; OrderedLocusNames=b2690, JW2665;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX MEDLINE=97349980; PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K.,
RA Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N.,
RA Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H.,
RA Oshima T., Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S.,
RA Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C.,
RA Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-
RT K12 genome corresponding to 50.0-68.8 min on the linkage map and
RT analysis of its sequence features.";
RL DNA Res. 4:91-113(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains
RT MG1655 and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP FUNCTION.
RX PubMed=15808744; DOI=10.1016/j.femsre.2004.12.006;
RA Kuznetsova E., Proudfoot M., Sanders S.A., Reinking J., Savchenko A.,
RA Arrowsmith C.H., Edwards A.M., Yakunin A.F.;
RT "Enzyme genomics: application of general enzymatic screens to discover
RT new enzymes.";
RL FEMS Microbiol. Rev. 29:263-279(2005).
CC -!- FUNCTION: Catalyzes the dephosphorylation of the artificial
CC chromogenic substrate p-nitrophenyl phosphate (pNPP) and of the
CC natural substrates fructose 1-phosphate and 6-phosphogluconate.
CC -!- INTERACTION:
CC P50456:mlc; NbExp=1; IntAct=EBI-371245, EBI-1116104;
CC -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily.
CC CbbY/cbbZ/gph/yieH family.
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DR EMBL; U00096; AAC75737.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA16557.1; -; Genomic_DNA.
DR PIR; C65049; C65049.
DR RefSeq; AP_003262.1; -.
DR RefSeq; NP_417175.1; -.
DR DIP; DIP:12842N; -.
DR IntAct; P77475; 5.
DR STRING; P77475; -.
DR GeneID; 945776; -.
DR GenomeReviews; AP009048_GR; JW2665.
DR GenomeReviews; U00096_GR; b2690.
DR KEGG; ecj:JW2665; -.
DR KEGG; eco:b2690; -.
DR EchoBASE; EB3301; -.
DR EcoGene; EG13530; yqaB.
DR HOGENOM; P77475; -.
DR OMA; HELFDES; -.
DR BioCyc; EcoCyc:G7408-MON; -.
DR BioCyc; MetaCyc:G7408-MON; -.
DR Genevestigator; P77475; -.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0005515; F:protein binding; IPI:IntAct.
DR GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR InterPro; IPR010976; B-phosphoglucomutase_hydrolase.
DR InterPro; IPR005834; Dehalogen-like_hydro.
DR InterPro; IPR006402; HAD-SF_hydro_IA_v3.
DR InterPro; IPR005833; Haloacid_DH/epoxide_hydro.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00413; HADHALOGNASE.
DR TIGRFAMs; TIGR01509; HAD-SF-IA-v3; 1.
DR TIGRFAMs; TIGR02009; PGMB-YQAB-SF; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Hydrolase.
FT CHAIN 1 188 Phosphatase yqaB.
FT /FTId=PRO_0000108063.
FT ACT_SITE 11 11 Nucleophile (By similarity).
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 8 183 ipfam:HAD_2 [T]
SQ SEQUENCE 188 AA; 20780 MW; AA3F9FF1DF3B2024 CRC64;
MYERYAGLIF DMDGTILDTE PTHRKAWREV LGHYGLQYDI QAMIALNGSP TWRIAQAIIE
LNQADLDPHA LAREKTEAVR SMLLDSVEPL PLVDVVKSWH GRRPMAVGTG SESAIAEALL
AHLGLRHYFD AVVAADHVKH HKPAPDTFLL CAQRMGVQPT QCVVFEDADF GIQAARAAGM
DAVDVRLL
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