ID YOHF_ECOLI Reviewed; 253 AA.
AC P33368; P33367; P76437; Q2MAU2;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-NOV-2009, entry version 66.
DE RecName: Full=Uncharacterized oxidoreductase yohF;
DE EC=1.-.-.-;
GN Name=yohF; Synonyms=yohE; OrderedLocusNames=b2137, JW2125;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / BHB2600;
RA Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K.,
RA Church G.M.;
RT "Automated multiplex sequencing of the E.coli genome.";
RL Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains
RT MG1655 and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC (SDR) family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA60499.1; Type=Frameshift; Positions=185; Note=Produces two separate ORFs;
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DR EMBL; U00007; AAA60500.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U00007; AAA60499.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U00096; AAC75198.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76614.1; -; Genomic_DNA.
DR PIR; H64981; H64981.
DR RefSeq; AP_002734.1; -.
DR RefSeq; NP_416641.1; -.
DR HSSP; P50163; 2AE1.
DR STRING; P33368; -.
DR GeneID; 949126; -.
DR GenomeReviews; AP009048_GR; JW2125.
DR GenomeReviews; U00096_GR; b2137.
DR KEGG; ecj:JW2125; -.
DR KEGG; eco:b2137; -.
DR EchoBASE; EB1955; -.
DR EcoGene; EG12019; yohF.
DR HOGENOM; P33368; -.
DR OMA; AGAMTKV; -.
DR BioCyc; EcoCyc:EG12019-MON; -.
DR Genevestigator; P33368; -.
DR GO; GO:0005488; F:binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR InterPro; IPR002347; Glc/ribitol_DH.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR PANTHER; PTHR19410; ADH_short_C2; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Complete proteome; Oxidoreductase.
FT CHAIN 1 253 Uncharacterized oxidoreductase yohF.
FT /FTId=PRO_0000054840.
FT NP_BIND 6 30 NAD or NADP (By similarity).
FT ACT_SITE 153 153 Proton acceptor (By similarity).
FT BINDING 140 140 Substrate (By similarity).
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 140 168 ipat:ADH_SHORT [T]
SQ SEQUENCE 253 AA; 26951 MW; B030F9EAD7E8F42A CRC64;
MAQVAIITAS DSGIGKECAL LLAQQGFDIG ITWHSDEEGA KDTAREVVSH GVRAEIVQLD
LGNLPEGALA LEKLIQRLGR IDVLVNNAGA MTKAPFLDMA FDEWRKIFTV DVDGAFLCSQ
IAARQMVKQG QGGRIINITS VHEHTPLPDA SAYTAAKHAL GGLTKAMALE LVRHKILVNA
VAPGAIATPM NGMDDSDVKP DAEPSIPLRR FGATHEIASL VVWLCSEGAN YTTGQSLIVD
GGFMLANPQF NPE
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