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To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=Phosphatase ybhA; EC=3.1.3.-; |
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| MyHits synonyms | YBHA_ECOLI , P21829 , BB4602AB4D26ACD2 |
 Legends: 1, ACT_SITE Nucleophile (By similarity); 2, Magnesium (By similarity).
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ID YBHA_ECOLI Reviewed; 272 AA.
AC P21829;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 3.
DT 03-NOV-2009, entry version 81.
DE RecName: Full=Phosphatase ybhA;
DE EC=3.1.3.-;
GN Name=ybhA; OrderedLocusNames=b0766, JW0749;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX MEDLINE=95394784; PubMed=7665460;
RA Maupin-Furlow J.A., Rosentel J.K., Lee J.H., Deppenmeier U.,
RA Gunsalus R.P., Shanmugam K.T.;
RT "Genetic analysis of the modABCD (molybdate transport) operon of
RT Escherichia coli.";
RL J. Bacteriol. 177:4851-4856(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / MC1000 / ATCC 39531;
RX MEDLINE=96151473; PubMed=8564363;
RA Walkenhorst H.M., Hemschemeier S.K., Eichenlaub R.;
RT "Molecular analysis of the molybdate uptake operon, modABCD, of
RT Escherichia coli and modR, a regulatory gene.";
RL Microbiol. Res. 150:347-361(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX MEDLINE=97061202; PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A.,
RA Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K.,
RA Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K.,
RA Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N.,
RA Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y.,
RA Yano M., Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome
RT corresponding to the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains
RT MG1655 and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [6]
RP FUNCTION.
RX PubMed=15808744; DOI=10.1016/j.femsre.2004.12.006;
RA Kuznetsova E., Proudfoot M., Sanders S.A., Reinking J., Savchenko A.,
RA Arrowsmith C.H., Edwards A.M., Yakunin A.F.;
RT "Enzyme genomics: application of general enzymatic screens to discover
RT new enzymes.";
RL FEMS Microbiol. Rev. 29:263-279(2005).
CC -!- FUNCTION: Catalyzes the dephosphorylation of the artificial
CC chromogenic substrate p-nitrophenyl phosphate (pNPP) and of the
CC natural substrates pyridoxalphosphate and erythrose 4-phosphate.
CC -!- COFACTOR: Magnesium (By similarity).
CC -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily. Cof
CC family.
CC -!- CAUTION: This ORF is coded on the other strand of an ORF which has
CC been called modD (by PubMed:7665460 and PubMed:8564363), but which
CC seems to be wrong.
CC -!- SEQUENCE CAUTION:
CC Sequence=U07867; Type=Frameshift; Positions=217;
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DR EMBL; U27192; AAB60177.1; -; Genomic_DNA.
DR EMBL; U07867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U00096; AAC73853.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA35430.1; -; Genomic_DNA.
DR PIR; F64812; F64812.
DR RefSeq; AP_001397.1; -.
DR RefSeq; NP_415287.1; -.
DR STRING; P21829; -.
DR GeneID; 945372; -.
DR GenomeReviews; AP009048_GR; JW0749.
DR GenomeReviews; U00096_GR; b0766.
DR KEGG; ecj:JW0749; -.
DR KEGG; eco:b0766; -.
DR EchoBASE; EB1221; -.
DR EcoGene; EG11239; ybhA.
DR HOGENOM; P21829; -.
DR OMA; TLGLECE; -.
DR BioCyc; EcoCyc:EG11239-MON; -.
DR BioCyc; MetaCyc:EG11239-MON; -.
DR Genevestigator; P21829; -.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0015662; F:ATPase activity, coupled to transmembrane m...; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006754; P:ATP biosynthetic process; IEA:InterPro.
DR InterPro; IPR001757; ATPase_P-typ_ion-transptr.
DR InterPro; IPR005834; Dehalogen-like_hydro.
DR InterPro; IPR006379; HAD-SF_hydro_IIB.
DR InterPro; IPR000150; Hypothet_cof.
DR PANTHER; PTHR11939; ATPase_P; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR TIGRFAMs; TIGR00099; Cof-subfamily; 1.
DR TIGRFAMs; TIGR01484; HAD-SF-IIB; 1.
DR PROSITE; PS01228; COF_1; 1.
DR PROSITE; PS01229; COF_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Hydrolase; Magnesium; Metal-binding.
FT CHAIN 1 272 Phosphatase ybhA.
FT /FTId=PRO_0000054420.
FT ACT_SITE 9 9 Nucleophile (By similarity).
FT METAL 9 9 Magnesium (By similarity).
FT METAL 11 11 Magnesium (By similarity).
FT METAL 223 223 Magnesium (By similarity).
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 6 267 ipfam:Hydrolase_3 [T]
SQ SEQUENCE 272 AA; 30201 MW; BB4602AB4D26ACD2 CRC64;
MTTRVIALDL DGTLLTPKKT LLPSSIEALA RAREAGYQLI IVTGRHHVAI HPFYQALALD
TPAICCNGTY LYDYHAKTVL EADPMPVIKA LQLIEMLNEH HIHGLMYVDD AMVYEHPTGH
VIRTSNWAQT LPPEQRPTFT QVASLAETAQ QVNAVWKFAL THDDLPQLQH FGKHVEHELG
LECEWSWHDQ VDIARGGNSK GKRLTKWVEA QGWSMENVVA FGDNFNDISM LEAAGTGVAM
GNADDAVKAR ANIVIGDNTT DSIAQFIYSH LI
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