ID RFAF_ECOLI Reviewed; 348 AA.
AC P37692; Q2M7T4;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-NOV-2009, entry version 79.
DE RecName: Full=ADP-heptose--LPS heptosyltransferase 2;
DE EC=2.-.-.-;
DE AltName: Full=ADP-heptose--LPS heptosyltransferase II;
GN Name=rfaF; Synonyms=waaF; OrderedLocusNames=b3620, JW3595;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX MEDLINE=94316500; PubMed=8041620; DOI=10.1093/nar/22.13.2576;
RA Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
RT "Analysis of the Escherichia coli genome. V. DNA sequence of the
RT region from 76.0 to 81.5 minutes.";
RL Nucleic Acids Res. 22:2576-2586(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains
RT MG1655 and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-51.
RC STRAIN=K12;
RX MEDLINE=90330578; PubMed=2198271;
RA Pegues J.C., Chen L., Gordon A.W., Ding L., Coleman W.G. Jr.;
RT "Cloning, expression, and characterization of the Escherichia coli K-
RT 12 rfaD gene.";
RL J. Bacteriol. 172:4652-4660(1990).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 52-348.
RC STRAIN=K12;
RX MEDLINE=93239678; PubMed=8478319;
RA Chen L., Coleman W.G. Jr.;
RT "Cloning and characterization of the Escherichia coli K-12 rfa-2
RT (rfaC) gene, a gene required for lipopolysaccharide inner core
RT synthesis.";
RL J. Bacteriol. 175:2534-2540(1993).
CC -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core
CC biosynthesis.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 9 family.
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DR EMBL; U00039; AAB18597.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76644.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77672.1; -; Genomic_DNA.
DR EMBL; M33577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X62530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; S47841; S47841.
DR RefSeq; AP_004171.1; -.
DR RefSeq; NP_418077.1; -.
DR PDB; 1PSW; X-ray; 2.00 A; A=1-348.
DR PDBsum; 1PSW; -.
DR DIP; DIP:10667N; -.
DR STRING; P37692; -.
DR CAZy; GT9; Glycosyltransferase Family 9.
DR GeneID; 948135; -.
DR GenomeReviews; AP009048_GR; JW3595.
DR GenomeReviews; U00096_GR; b3620.
DR KEGG; ecj:JW3595; -.
DR KEGG; eco:b3620; -.
DR EchoBASE; EB2124; -.
DR EcoGene; EG12210; rfaF.
DR HOGENOM; P37692; -.
DR OMA; YDQAILL; -.
DR BioCyc; EcoCyc:EG12210-MON; -.
DR BioCyc; MetaCyc:EG12210-MON; -.
DR Genevestigator; P37692; -.
DR GO; GO:0016757; F:transferase activity, transferring glycosyl...; IEA:UniProtKB-KW.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR002201; Glyco_trans_9.
DR InterPro; IPR011910; Heptsyl_trn_II.
DR Pfam; PF01075; Glyco_transf_9; 1.
DR TIGRFAMs; TIGR02195; heptsyl_trn_II; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Glycosyltransferase;
KW Lipopolysaccharide biosynthesis; Transferase.
FT CHAIN 1 348 ADP-heptose--LPS heptosyltransferase 2.
FT /FTId=PRO_0000207262.
FT CONFLICT 16 16 Missing (in Ref. 4; M33577).
FT CONFLICT 19 20 SL -> DR (in Ref. 4; M33577).
FT CONFLICT 105 105 R -> S (in Ref. 5).
FT CONFLICT 151 151 L -> R (in Ref. 5).
FT CONFLICT 159 159 Q -> H (in Ref. 5).
FT CONFLICT 204 205 EL -> DV (in Ref. 5).
FT STRAND 2 6
FT HELIX 11 27
FT STRAND 32 37
FT HELIX 39 41
FT HELIX 42 45
FT STRAND 51 56
FT HELIX 66 75
FT TURN 76 80
FT STRAND 82 86
FT HELIX 92 94
FT HELIX 95 99
FT STRAND 103 108
FT TURN 110 112
FT TURN 114 116
FT STRAND 119 121
FT TURN 125 127
FT HELIX 131 137
FT HELIX 142 144
FT HELIX 148 150
FT HELIX 164 173
FT STRAND 178 180
FT STRAND 182 186
FT HELIX 193 195
FT HELIX 199 211
FT STRAND 215 218
FT HELIX 222 224
FT HELIX 225 232
FT HELIX 237 240
FT STRAND 243 245
FT TURN 247 249
FT HELIX 252 260
FT STRAND 262 270
FT HELIX 271 278
FT STRAND 283 290
FT STRAND 302 308
FT HELIX 325 328
FT HELIX 332 347
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 69 324 ipfam:Glyco_transf_9 [T]
SQ SEQUENCE 348 AA; 39042 MW; C5F57BC94B15BA6A CRC64;
MKILVIGPSW VGDMMMSQSL YRTLQARYPQ AIIDVMAPAW CRPLLSRMPE VNEAIPMPLG
HGALEIGERR KLGHSLREKR YDRAYVLPNS FKSALVPFFA GIPHRTGWRG EMRYGLLNDV
RVLDKEAWPL MVERYIALAY DKGIMRTAQD LPQPLLWPQL QVSEGEKSYT CNQFSLSSER
PMIGFCPGAE FGPAKRWPHY HYAELAKQLI DEGYQVVLFG SAKDHEAGNE ILAALNTEQQ
AWCRNLAGET QLDQAVILIA ACKAIVTNDS GLMHVAAALN RPLVALYGPS SPDFTPPLSH
KARVIRLITG YHKVRKGDAA EGYHQSLIDI TPQRVLEELN ALLLQEEA
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