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Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=N-acetylglucosamine-6-phosphate deacetylase; EC=3.5.1.25; AltName: Full=GlcNAc 6-P deacetylase; |
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| MyHits synonyms | NAGA_ECOLI , P0AF18 , P15300 , A10B015ADFC98FCA |
 Legends: 1, STRAND; 2, HELIX; 3, TURN.
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ID NAGA_ECOLI Reviewed; 382 AA.
AC P0AF18; P15300;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-NOV-2009, entry version 37.
DE RecName: Full=N-acetylglucosamine-6-phosphate deacetylase;
DE EC=3.5.1.25;
DE AltName: Full=GlcNAc 6-P deacetylase;
GN Name=nagA; OrderedLocusNames=b0677, JW0663;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX MEDLINE=89343637; PubMed=2668691;
RX DOI=10.1111/j.1365-2958.1989.tb00197.x;
RA Plumbridge J.;
RT "Sequence of the nagBACD operon in Escherichia coli K12 and pattern of
RT transcription within the nag regulon.";
RL Mol. Microbiol. 3:505-515(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX MEDLINE=90274974; PubMed=2190615;
RA Peri K.G., Goldie H., Waygood E.B.;
RT "Cloning and characterization of the N-acetylglucosamine operon of
RT Escherichia coli.";
RL Biochem. Cell Biol. 68:123-137(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX MEDLINE=97061202; PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A.,
RA Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K.,
RA Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K.,
RA Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N.,
RA Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y.,
RA Yano M., Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome
RT corresponding to the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains
RT MG1655 and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [6]
RP INDUCTION.
RC STRAIN=K12;
RX PubMed=12813061; DOI=10.1128/JB.185.13.3696-3702.2003;
RA Minagawa S., Ogasawara H., Kato A., Yamamoto K., Eguchi Y., Oshima T.,
RA Mori H., Ishihama A., Utsumi R.;
RT "Identification and molecular characterization of the Mg2+ stimulon of
RT Escherichia coli.";
RL J. Bacteriol. 185:3696-3702(2003).
CC -!- CATALYTIC ACTIVITY: N-acetyl-D-glucosamine 6-phosphate + H(2)O =
CC D-glucosamine 6-phosphate + acetate.
CC -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation;
CC D-fructose 6-phosphate from N-acetylneuraminate: step 4/5.
CC -!- INDUCTION: By N-acetylglucosamine. Induced by low extracellular
CC levels of magnesium via the phoQ/phoP two-component regulatory
CC system.
CC -!- SIMILARITY: Belongs to the nagA family.
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DR EMBL; X14135; CAA32353.1; -; Genomic_DNA.
DR EMBL; AF052007; AAC09325.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73771.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA35320.1; -; Genomic_DNA.
DR PIR; A37018; A37018.
DR RefSeq; AP_001315.1; -.
DR RefSeq; NP_415203.1; -.
DR PDB; 1YMY; X-ray; 2.60 A; A/B=1-382.
DR PDB; 1YRR; X-ray; 2.00 A; A/B=1-18.
DR PDB; 2P50; X-ray; 2.20 A; A/B/C/D=1-382.
DR PDB; 2P53; X-ray; 2.10 A; A/B=1-382.
DR PDBsum; 1YMY; -.
DR PDBsum; 1YRR; -.
DR PDBsum; 2P50; -.
DR PDBsum; 2P53; -.
DR STRING; P0AF18; -.
DR GeneID; 945289; -.
DR GenomeReviews; AP009048_GR; JW0663.
DR GenomeReviews; U00096_GR; b0677.
DR KEGG; ecj:JW0663; -.
DR KEGG; eco:b0677; -.
DR EchoBASE; EB0626; -.
DR EcoGene; EG10632; nagA.
DR HOGENOM; P0AF18; -.
DR OMA; ETMQIMH; -.
DR BioCyc; EcoCyc:NAG6PDEACET-MON; -.
DR BioCyc; MetaCyc:NAG6PDEACET-MON; -.
DR Genevestigator; P0AF18; -.
DR GO; GO:0008448; F:N-acetylglucosamine-6-phosphate deacetylase...; IEA:EC.
DR GO; GO:0006044; P:N-acetylglucosamine metabolic process; IEA:InterPro.
DR InterPro; IPR006680; Amidohydro_1.
DR InterPro; IPR003764; GlcNAc_6-P_deAcase.
DR Pfam; PF01979; Amidohydro_1; 1.
DR ProDom; PD001248; Amidohydro_like; 1.
DR TIGRFAMs; TIGR00221; nagA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Carbohydrate metabolism; Complete proteome; Hydrolase.
FT CHAIN 1 382 N-acetylglucosamine-6-phosphate
FT deacetylase.
FT /FTId=PRO_0000170915.
FT STRAND 2 10
FT STRAND 15 24
FT STRAND 27 33
FT HELIX 34 36
FT STRAND 43 45
FT STRAND 50 53
FT STRAND 55 63
FT STRAND 66 71
FT TURN 72 74
FT HELIX 77 89
FT STRAND 92 100
FT HELIX 104 120
FT STRAND 128 131
FT HELIX 150 161
FT TURN 162 165
FT STRAND 166 171
FT HELIX 173 175
FT HELIX 178 186
FT STRAND 190 193
FT HELIX 200 209
FT STRAND 213 216
FT TURN 217 220
FT HELIX 230 237
FT STRAND 242 246
FT STRAND 248 252
FT HELIX 254 264
FT HELIX 265 267
FT STRAND 268 271
FT TURN 276 279
FT STRAND 283 287
FT STRAND 290 294
FT STRAND 306 309
FT HELIX 313 324
FT HELIX 328 335
FT HELIX 337 342
FT TURN 346 348
FT STRAND 349 351
FT STRAND 360 363
FT STRAND 369 374
FT STRAND 377 381
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 50 379 ipfam:Amidohydro_1 [T]
SQ SEQUENCE 382 AA; 40949 MW; A10B015ADFC98FCA CRC64;
MYALTQGRIF TGHEFLDDHA VVIADGLIKS VCPVAELPPE IEQRSLNGAI LSPGFIDVQL
NGCGGVQFND TAEAVSVETL EIMQKANEKS GCTNYLPTLI TTSDELMKQG VRVMREYLAK
HPNQALGLHL EGPWLNLVKK GTHNPNFVRK PDAALVDFLC ENADVITKVT LAPEMVPAEV
ISKLANAGIV VSAGHSNATL KEAKAGFRAG ITFATHLYNA MPYITGREPG LAGAILDEAD
IYCGIIADGL HVDYANIRNA KRLKGDKLCL VTDATAPAGA NIEQFIFAGK TIYYRNGLCV
DENGTLSGSS LTMIEGVRNL VEHCGIALDE VLRMATLYPA RAIGVEKRLG TLAAGKVANL
TAFTPDFKIT KTIVNGNEVV TQ
//
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