ID KDPD_ECOLI Reviewed; 894 AA.
AC P21865;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 2.
DT 03-NOV-2009, entry version 95.
DE RecName: Full=Sensor protein kdpD;
DE EC=2.7.13.3;
GN Name=kdpD; OrderedLocusNames=b0695, JW0683;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX MEDLINE=92202141; PubMed=1532388;
RA Walderhaug M.O., Polarek J.W., Voelkner P., Daniel J.M., Hesse J.E.,
RA Altendorf K., Epstein W.;
RT "KdpD and KdpE, proteins that control expression of the kdpABC operon,
RT are members of the two-component sensor-effector class of
RT regulators.";
RL J. Bacteriol. 174:2152-2159(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX MEDLINE=97061202; PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A.,
RA Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K.,
RA Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K.,
RA Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N.,
RA Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y.,
RA Yano M., Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome
RT corresponding to the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains
RT MG1655 and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP TOPOLOGY.
RX MEDLINE=96081868; PubMed=7499326; DOI=10.1074/jbc.270.47.28282;
RA Zimmann P., Puppe W., Altendorf K.;
RT "Membrane topology analysis of the sensor kinase KdpD of Escherichia
RT coli.";
RL J. Biol. Chem. 270:28282-28288(1995).
RN [6]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Member of the two-component regulatory system kdpD/kdpE
CC involved in the regulation of the kdp operon. KdpD may function as
CC a membrane-associated protein kinase that phosphorylates kdpE in
CC response to environmental signals.
CC -!- CATALYTIC ACTIVITY: ATP + protein L-histidine = ADP + protein N-
CC phospho-L-histidine.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Contains 1 histidine kinase domain.
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DR EMBL; M36066; AAA24041.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73789.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA35352.1; -; Genomic_DNA.
DR PIR; B42372; B42372.
DR RefSeq; AP_001333.1; -.
DR RefSeq; NP_415223.1; -.
DR HSSP; P23837; 1ID0.
DR DIP; DIP:10062N; -.
DR STRING; P21865; -.
DR GeneID; 946744; -.
DR GenomeReviews; AP009048_GR; JW0683.
DR GenomeReviews; U00096_GR; b0695.
DR KEGG; ecj:JW0683; -.
DR KEGG; eco:b0695; -.
DR EchoBASE; EB0511; -.
DR EcoGene; EG10516; kdpD.
DR HOGENOM; P21865; -.
DR OMA; FLPMRTG; -.
DR BioCyc; EcoCyc:KDPD-MON; -.
DR BRENDA; 2.7.13.3; 246.
DR Genevestigator; P21865; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:two-component sensor activity; IEA:InterPro.
DR GO; GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro.
DR GO; GO:0006950; P:response to stress; IEA:InterPro.
DR GO; GO:0000160; P:two-component signal transduction system (p...; IEA:UniProtKB-KW.
DR InterPro; IPR003594; ATP_bd_ATPase.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003661; Sig_transdc_His_kin_sub1_dim/P.
DR InterPro; IPR005467; Sig_transdc_His_kinase_core.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR InterPro; IPR006016; UspA.
DR Gene3D; G3DSA:3.30.565.10; ATP_bd_ATPase; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR ProDom; PD011725; KdpD; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cell inner membrane; Cell membrane; Complete proteome;
KW Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Transferase;
KW Transmembrane; Two-component regulatory system.
FT CHAIN 1 894 Sensor protein kdpD.
FT /FTId=PRO_0000074772.
FT TOPO_DOM 1 400 Cytoplasmic (Probable).
FT TRANSMEM 401 423 Probable.
FT TOPO_DOM 424 427 Periplasmic (Probable).
FT TRANSMEM 428 444 Probable.
FT TOPO_DOM 445 445 Cytoplasmic (Probable).
FT TRANSMEM 446 466 Probable.
FT TOPO_DOM 467 474 Periplasmic (Probable).
FT TRANSMEM 475 498 Probable.
FT TOPO_DOM 499 894 Cytoplasmic (Probable).
FT DOMAIN 670 883 Histidine kinase.
FT MOD_RES 673 673 Phosphohistidine; by autocatalysis (By
FT similarity).
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 664 730 ipfam:HisKA [T]
FT MYHIT 527 644 ipfam:GAF_3 [T]
FT MYHIT 403 507 ipfam:DUF4118 [T]
FT MYHIT 21 230 ipfam:KdpD [T]
FT MYHIT 663 730 ismart:HisKA [T]
FT MYHIT 670 883 iprf:HIS_KIN [T]
FT MYHIT 777 882 ipfam:HATPase_c [T]
FT MYHIT 773 883 ismart:HATPase_c [T]
SQ SEQUENCE 894 AA; 98718 MW; E9D2749B4CAA12DA CRC64;
MNNEPLRPDP DRLLEQTAAP HRGKLKVFFG ACAGVGKTWA MLAEAQRLRA QGLDIVVGVV
ETHGRKDTAA MLEGLAVLPL KRQAYRGRHI SEFDLDAALA RRPALILMDE LAHSNAPGSR
HPKRWQDIEE LLEAGIDVFT TVNVQHLESL NDVVSGVTGI QVRETVPDPF FDAADDVVLV
DLPPDDLRQR LKEGKVYIAG QAERAIEHFF RKGNLIALRE LALRRTADRV DEQMRAWRGH
PGEEKVWHTR DAILLCIGHN TGSEKLVRAA ARLASRLGSV WHAVYVETPA LHRLPEKKRR
AILSALRLAQ ELGAETATLS DPAEEKAVVR YAREHNLGKI ILGRPASRRW WRRETFADRL
ARIAPDLDQV LVALDEPPAR TINNAPDNRS FKDKWRVQIQ GCVVAAALCA VITLIAMQWL
MAFDAANLVM LYLLGVVVVA LFYGRWPSVV ATVINVVSFD LFFIAPRGTL AVSDVQYLLT
FAVMLTVGLV IGNLTAGVRY QARVARYREQ RTRHLYEMSK ALAVGRSPQD IAATSEQFIA
STFHARSQVL LPDDNGKLQP LTHPQGMTPW DDAIAQWSFD KGLPAGAGTD TLPGVPYQIL
PLKSGEKTYG LVVVEPGNLR QLMIPEQQRL LETFTLLVAN ALERLTLTAS EEQARMASER
EQIRNALLAA LSHDLRTPLT VLFGQAEILT LDLASEGSPH ARQASEIRQH VLNTTRLVNN
LLDMARIQSG GFNLKKEWLT LEEVVGSALQ MLEPGLSSPI NLSLPEPLTL IHVDGPLFER
VLINLLENAV KYAGAQAEIG IDAHVEGENL QLDVWDNGPG LPPGQEQTIF DKFARGNKES
AVPGVGLGLA ICRAIVDVHG GTITAFNRPE GGACFRVTLP QQTAPELEEF HEDM
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