Entry ecoli:INTD_ECOLI

ID   INTD_ECOLI              Reviewed;         387 AA.
AC   P24218; Q2MBP3;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   03-NOV-2009, entry version 63.
DE   RecName: Full=Prophage DLP12 integrase;
DE   AltName: Full=Prophage QSR' integrase;
GN   Name=intD; Synonyms=int; OrderedLocusNames=b0537, JW0525;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   MEDLINE=90036709; PubMed=2553674;
RA   Lindsey D.F., Mullin D.A., Walker J.R.;
RT   "Characterization of the cryptic lambdoid prophage DLP12 of
RT   Escherichia coli and overlap of the DLP12 integrase gene with the tRNA
RT   gene argU.";
RL   J. Bacteriol. 171:6197-6205(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=90220507; PubMed=2183007; DOI=10.1007/BF00260503;
RA   Muramatsu S., Mizuno T.;
RT   "Nucleotide sequence of the region encompassing the int gene of a
RT   cryptic prophage and the DNA Y gene flanked by a curved DNA sequence
RT   of Escherichia coli K12.";
RL   Mol. Gen. Genet. 220:325-328(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA   Mau B., Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1474(1997).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains
RT   MG1655 and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Integrase from the cryptic lambdoic prophage DLP12.
CC       Integrase is necessary for integration of the phage into the host
CC       genome by site-specific recombination. In conjunction with
CC       excisionase, integrase is also necessary for excision of the
CC       prophage from the host genome.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family.
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DR   EMBL; M31074; AAA65483.1; -; Genomic_DNA.
DR   EMBL; M27155; AAA24030.1; -; Genomic_DNA.
DR   EMBL; X51662; CAA35974.1; -; Genomic_DNA.
DR   EMBL; U82598; AAB40734.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC73638.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76313.1; -; Genomic_DNA.
DR   PIR; A33497; A33497.
DR   RefSeq; AP_001183.1; -.
DR   RefSeq; NP_415069.1; -.
DR   HSSP; P21442; 1AIH.
DR   STRING; P24218; -.
DR   PRIDE; P24218; -.
DR   GeneID; 947162; -.
DR   GenomeReviews; AP009048_GR; JW0525.
DR   GenomeReviews; U00096_GR; b0537.
DR   KEGG; ecj:JW0525; -.
DR   KEGG; eco:b0537; -.
DR   EchoBASE; EB0502; -.
DR   EcoGene; EG10507; intD.
DR   HOGENOM; P24218; -.
DR   OMA; GETWYAS; -.
DR   BioCyc; EcoCyc:EG10507-MON; -.
DR   Genevestigator; P24218; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   InterPro; IPR013762; Integrase-like_cat-core_phage.
DR   InterPro; IPR002104; Integrase_cat-core_phage.
DR   Gene3D; G3DSA:1.10.443.10; Phage_intgr_like; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
PE   3: Inferred from homology;
KW   Complete proteome; DNA integration; DNA recombination.
FT   CHAIN         1    387       Prophage DLP12 integrase.
FT                                /FTId=PRO_0000197513.
FT   ACT_SITE    349    349       O-(3'-phospho-DNA)-tyrosine intermediate
FT                                (By similarity).
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       185    353       ipfam:Phage_integrase [T]
SQ   SEQUENCE   387 AA;  45090 MW;  E3DB8A8D0A613F64 CRC64;
     MSLFRRNEIW YASYSLPGGK RIKESLGTKD KRQAQELHDK RKAELWRVEK LGDLPDVTFE
     EACLRWLEEK ADKKSLDSDK SRIEFWLEHF EGIRLKDISE AKIYSAVSRM HNRKTKEIWK
     QKVQAAIRKG KELPVYEPKP VSTQTKAKHL AMIKAILRAA ERDWKWLEKA PVIKIPAVRN
     KRVRWLEKEE AKRLIDECPE PLKSVVKFAL ATGLRKSNII NLEWQQIDMQ RRVAWVNPEE
     SKSNRAIGVA LNDTACKVLR DQIGKHHKWV FVHTKAAKRA DGTSTPAVRK MRIDSKTSWL
     SACRRAGIED FRFHDLRHTW ASWLIQSGVP LSVLQEMGGW ESIEMVRRYA HLAPNHLTEH
     ARKIDDIFGD NVPNMSHSEI MEDIKKA
//