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MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=L-fucose-proton symporter; AltName: Full=L-fucose permease; AltName: Full=6-deoxy-L-galactose permease; |
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| MyHits synonyms | FUCP_ECOLI , P11551 , Q2MA33 , D8AA3785274A0085 |
 Legends: 1, TOPO_DOM Cytoplasmic (Probable); 2, TRANSMEM Probable; 3, TOPO_DOM Periplasmic (Probable).
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ID FUCP_ECOLI Reviewed; 438 AA.
AC P11551; Q2MA33;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-NOV-2009, entry version 84.
DE RecName: Full=L-fucose-proton symporter;
DE AltName: Full=L-fucose permease;
DE AltName: Full=6-deoxy-L-galactose permease;
GN Name=fucP; OrderedLocusNames=b2801, JW2772;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX MEDLINE=89315234; PubMed=2664711; DOI=10.1093/nar/17.12.4883;
RA Lu Z., Lin E.C.C.;
RT "The nucleotide sequence of Escherichia coli genes for L-fucose
RT dissimilation.";
RL Nucleic Acids Res. 17:4883-4884(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains
RT MG1655 and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
RX MEDLINE=90036697; PubMed=2553671;
RA Chen Y.M., Lu Z., Lin E.C.C.;
RT "Constitutive activation of the fucAO operon and silencing of the
RT divergently transcribed fucPIK operon by an IS5 element in Escherichia
RT coli mutants selected for growth on L-1,2-propanediol.";
RL J. Bacteriol. 171:6097-6105(1989).
RN [5]
RP PROTEIN SEQUENCE OF 2-21, AND CHARACTERIZATION.
RX MEDLINE=94328931; PubMed=8052131;
RX DOI=10.1111/j.1365-2958.1994.tb01066.x;
RA Gunn F.J., Tate C.G., Henderson P.J.F.;
RT "Identification of a novel sugar-H+ symport protein, FucP, for
RT transport of L-fucose into Escherichia coli.";
RL Mol. Microbiol. 12:799-809(1994).
RN [6]
RP FUNCTION, AND TRANSCRIPTIONAL REGULATION.
RX MEDLINE=88133900; PubMed=2829831;
RA Bradley S.A., Tinsley C.R., Muiry J.A., Henderson P.J.F.;
RT "Proton-linked L-fucose transport in Escherichia coli.";
RL Biochem. J. 248:495-500(1987).
RN [7]
RP TOPOLOGY.
RX MEDLINE=95302988; PubMed=7783647;
RX DOI=10.1111/j.1365-2958.1995.tb02384.x;
RA Gunn F.J., Tate C.G., Sansom C.E., Henderson P.J.F.;
RT "Topological analyses of the L-fucose-H+ symport protein, FucP, from
RT Escherichia coli.";
RL Mol. Microbiol. 15:771-783(1995).
RN [8]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Mediates the uptake of L-fucose across the boundary
CC membrane with the concomitant transport of protons into the cell
CC (symport system). Can also transport L-galactose and D-arabinose,
CC but at reduced rates compared with L-fucose. Is not able to
CC transport L-rhamnose and L-arabinose.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC protein.
CC -!- INDUCTION: By L-fucose.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. FHS
CC transporter (TC 2.A.1.7) family.
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DR EMBL; X15025; CAA33126.1; -; Genomic_DNA.
DR EMBL; U29581; AAB40451.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75843.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76873.1; -; Genomic_DNA.
DR EMBL; M31059; AAA23822.2; -; Genomic_DNA.
DR PIR; JS0184; WQECFP.
DR RefSeq; AP_003367.1; -.
DR RefSeq; NP_417281.1; -.
DR STRING; P11551; -.
DR TCDB; 2.A.1.7.1; major facilitator superfamily (MFS).
DR GeneID; 947487; -.
DR GenomeReviews; AP009048_GR; JW2772.
DR GenomeReviews; U00096_GR; b2801.
DR KEGG; ecj:JW2772; -.
DR KEGG; eco:b2801; -.
DR EchoBASE; EB0348; -.
DR EcoGene; EG10352; fucP.
DR HOGENOM; P11551; -.
DR OMA; GAYFIIA; -.
DR BioCyc; EcoCyc:FUCP-MON; -.
DR Genevestigator; P11551; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0006004; P:fucose metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR005275; Lfuc_permease.
DR InterPro; IPR011701; MFS_1.
DR Pfam; PF07690; MFS_1; 1.
DR TIGRFAMs; TIGR00885; fucP; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Carbohydrate metabolism; Cell inner membrane; Cell membrane;
KW Complete proteome; Direct protein sequencing; Fucose metabolism;
KW Membrane; Sugar transport; Symport; Transmembrane; Transport.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 438 L-fucose-proton symporter.
FT /FTId=PRO_0000094501.
FT TOPO_DOM 2 24 Cytoplasmic (Probable).
FT TRANSMEM 25 45 Probable.
FT TOPO_DOM 46 55 Periplasmic (Probable).
FT TRANSMEM 56 76 Probable.
FT TOPO_DOM 77 95 Cytoplasmic (Probable).
FT TRANSMEM 96 115 Probable.
FT TOPO_DOM 116 118 Periplasmic (Probable).
FT TRANSMEM 119 139 Probable.
FT TOPO_DOM 140 166 Cytoplasmic (Probable).
FT TRANSMEM 167 187 Probable.
FT TOPO_DOM 188 206 Periplasmic (Probable).
FT TRANSMEM 207 227 Probable.
FT TOPO_DOM 228 265 Cytoplasmic (Probable).
FT TRANSMEM 266 286 Probable.
FT TOPO_DOM 287 295 Periplasmic (Probable).
FT TRANSMEM 296 316 Probable.
FT TOPO_DOM 317 326 Cytoplasmic (Probable).
FT TRANSMEM 327 347 Probable.
FT TOPO_DOM 348 352 Periplasmic (Probable).
FT TRANSMEM 353 373 Probable.
FT TOPO_DOM 374 381 Cytoplasmic (Probable).
FT TRANSMEM 382 402 Probable.
FT TOPO_DOM 403 413 Periplasmic (Probable).
FT TRANSMEM 414 434 Probable.
FT TOPO_DOM 435 438 Cytoplasmic (Probable).
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 27 437 iprf:MFS [T]
FT MYHIT 33 387 ipfam:MFS_1 [T]
SQ SEQUENCE 438 AA; 47545 MW; D8AA3785274A0085 CRC64;
MGNTSIQTQS YRAVDKDAGQ SRSYIIPFAL LCSLFFLWAV ANNLNDILLP QFQQAFTLTN
FQAGLIQSAF YFGYFIIPIP AGILMKKLSY KAGIITGLFL YALGAALFWP AAEIMNYTLF
LVGLFIIAAG LGCLETAANP FVTVLGPESS GHFRLNLAQT FNSFGAIIAV VFGQSLILSN
VPHQSQDVLD KMSPEQLSAY KHSLVLSVQT PYMIIVAIVL LVALLIMLTK FPALQSDNHS
DAKQGSFSAS LSRLARIRHW RWAVLAQFCY VGAQTACWSY LIRYAVEEIP GMTAGFAANY
LTGTMVCFFI GRFTGTWLIS RFAPHKVLAA YALIAMALCL ISAFAGGHVG LIALTLCSAF
MSIQYPTIFS LGIKNLGQDT KYGSSFIVMT IIGGGIVTPV MGFVSDAAGN IPTAELIPAL
CFAVIFIFAR FRSQTATN
//
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