ID CYOC_ECOLI Reviewed; 204 AA.
AC P0ABJ3; P18402; Q2MBZ6;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 03-NOV-2009, entry version 37.
DE RecName: Full=Cytochrome o ubiquinol oxidase subunit 3;
DE EC=1.10.3.-;
DE AltName: Full=Cytochrome o ubiquinol oxidase subunit III;
DE AltName: Full=Ubiquinol oxidase chain C;
GN Name=cyoC; OrderedLocusNames=b0430, JW0420;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=90293062; PubMed=2162835;
RA Chepuri V., Lemieux L., Au D.C.T., Gennis R.B.;
RT "The sequence of the cyo operon indicates substantial structural
RT similarities between the cytochrome o ubiquinol oxidase of Escherichia
RT coli and the aa3-type family of cytochrome c oxidases.";
RL J. Biol. Chem. 265:11185-11192(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains
RT MG1655 and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP TOPOLOGY.
RX MEDLINE=90330636; PubMed=2165491;
RA Chepuri V., Gennis R.B.;
RT "The use of gene fusions to determine the topology of all of the
RT subunits of the cytochrome o terminal oxidase complex of Escherichia
RT coli.";
RL J. Biol. Chem. 265:12978-12986(1990).
RN [6]
RP TOPOLOGY.
RX MEDLINE=90366572; PubMed=2168206; DOI=10.1016/0005-2728(90)90231-R;
RA Chepuri V., Lemieux L., Hill J., Alben J.O., Gennis R.B.;
RT "Recent studies of the cytochrome o terminal oxidase complex of
RT Escherichia coli.";
RL Biochim. Biophys. Acta 1018:124-127(1990).
RN [7]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS).
RX MEDLINE=20473233; PubMed=11017202; DOI=10.1038/82824;
RA Abramson J., Riistama S., Larsson G., Jasaitis A., Svensson-Ek M.,
RA Puustinen A., Iwata S., Wikstrom M.;
RT "The structure of the ubiquinol oxidase from Escherichia coli and its
RT ubiquinone binding site.";
RL Nat. Struct. Biol. 7:910-917(2000).
CC -!- FUNCTION: Cytochrome o terminal oxidase complex is the component
CC of the aerobic respiratory chain of E.coli that predominates when
CC cells are grown at high aeration.
CC -!- CATALYTIC ACTIVITY: Ubiquinol-8 + O(2) = Ubiquinone-8 + H(2)O.
CC -!- SUBUNIT: Heterooctamer of two A chains, two B chains, two C chains
CC and two D chains.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
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DR EMBL; J05492; AAA23633.1; -; Genomic_DNA.
DR EMBL; U82664; AAB40186.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73533.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76210.1; -; Genomic_DNA.
DR PIR; C42226; C42226.
DR RefSeq; AP_001080.1; -.
DR RefSeq; NP_414964.1; -.
DR PDB; 1FFT; X-ray; 3.50 A; C/H=1-204.
DR PDBsum; 1FFT; -.
DR STRING; P0ABJ3; -.
DR TCDB; 3.D.4.5.1; proton-translocating cytochrome oxidase (COX) superfamily.
DR GeneID; 946897; -.
DR GenomeReviews; AP009048_GR; JW0420.
DR GenomeReviews; U00096_GR; b0430.
DR KEGG; ecj:JW0420; -.
DR KEGG; eco:b0430; -.
DR EchoBASE; EB0177; -.
DR EcoGene; EG10180; cyoC.
DR HOGENOM; P0ABJ3; -.
DR OMA; LDHAASH; -.
DR BioCyc; EcoCyc:CYOC-MON; -.
DR BioCyc; MetaCyc:CYOC-MON; -.
DR Genevestigator; P0ABJ3; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR GO; GO:0016682; F:oxidoreductase activity, acting on diphenol...; IEA:InterPro.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrom...; IEA:InterPro.
DR GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR InterPro; IPR000298; Cyt_c_oxidase_su3.
DR InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR InterPro; IPR014206; Cyt_c_ubiqinol_oxidase_su3.
DR Gene3D; G3DSA:1.20.120.80; CytC_oxdse_III_a-bundle; 1.
DR PANTHER; PTHR11403; CytC_oxdse_III; 1.
DR Pfam; PF00510; COX3; 1.
DR ProDom; PD000382; CytC_oxdse_III; 1.
DR TIGRFAMs; TIGR02842; CyoC; 1.
DR PROSITE; PS50253; COX3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell inner membrane; Cell membrane; Complete proteome;
KW Electron transport; Membrane; Oxidoreductase; Transmembrane;
KW Transport.
FT CHAIN 1 204 Cytochrome o ubiquinol oxidase subunit 3.
FT /FTId=PRO_0000183893.
FT TOPO_DOM 1 31 Cytoplasmic (Probable).
FT TRANSMEM 32 50 Probable.
FT TOPO_DOM 51 66 Periplasmic (Probable).
FT TRANSMEM 67 85 Probable.
FT TOPO_DOM 86 101 Cytoplasmic (Probable).
FT TRANSMEM 102 120 Probable.
FT TOPO_DOM 121 142 Periplasmic (Probable).
FT TRANSMEM 143 161 Probable.
FT TOPO_DOM 162 184 Cytoplasmic (Probable).
FT TRANSMEM 185 203 Probable.
FT TOPO_DOM 204 204 Periplasmic (Probable).
FT HELIX 24 30
FT HELIX 33 36
FT HELIX 39 47
FT TURN 48 53
FT HELIX 66 76
FT HELIX 77 79
FT TURN 80 84
FT HELIX 86 88
FT TURN 89 92
FT HELIX 95 98
FT HELIX 100 125
FT TURN 135 137
FT HELIX 138 146
FT HELIX 149 152
FT HELIX 155 166
FT HELIX 176 194
FT HELIX 195 202
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 1 203 iprf:COX3 [T]
FT MYHIT 16 202 ipfam:COX3 [T]
SQ SEQUENCE 204 AA; 22623 MW; F1D6ABF9EB6CB5AD CRC64;
MATDTLTHAT AHAHEHGHHD AGGTKIFGFW IYLMSDCILF SILFATYAVL VNGTAGGPTG
KDIFELPFVL VETFLLLFSS ITYGMAAIAM YKNNKSQVIS WLALTWLFGA GFIGMEIYEF
HHLIVNGMGP DRSGFLSAFF ALVGTHGLHV TSGLIWMAVL MVQIARRGLT STNRTRIMCL
SLFWHFLDVV WICVFTVVYL MGAM
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