ID YNFM_ECOLI Reviewed; 417 AA.
AC P43531; P76886; P77705;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 15-FEB-2017, entry version 120.
DE RecName: Full=Inner membrane transport protein YnfM;
GN Name=ynfM; Synonyms=yzyC; OrderedLocusNames=b1596, JW1588;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M.,
RA Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K.,
RA Nakade S., Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N.,
RA Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J.,
RA Takemoto K., Takeuchi Y., Wada C., Yamamoto Y., Horiuchi T.;
RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome
RT corresponding to the 28.0-40.1 min region on the linkage map.";
RL DNA Res. 3:363-377(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains
RT MG1655 and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 350-417.
RC STRAIN=K12 / N2212;
RA Jakubcionyte E., Apirion D., Normark S.;
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION.
RA Rudd K.E.;
RL Unpublished observations (JUL-1995).
RN [6]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; U00096; AAC74668.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15330.1; -; Genomic_DNA.
DR EMBL; AF405541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; F64915; F64915.
DR RefSeq; NP_416113.1; NC_000913.3.
DR RefSeq; WP_000091840.1; NZ_LN832404.1.
DR ProteinModelPortal; P43531; -.
DR BioGrid; 4259121; 139.
DR STRING; 511145.b1596; -.
DR TCDB; 2.A.1.36.1; the major facilitator superfamily (mfs).
DR PaxDb; P43531; -.
DR PRIDE; P43531; -.
DR EnsemblBacteria; AAC74668; AAC74668; b1596.
DR EnsemblBacteria; BAA15330; BAA15330; BAA15330.
DR GeneID; 946138; -.
DR KEGG; ecj:JW1588; -.
DR KEGG; eco:b1596; -.
DR PATRIC; 32118494; VBIEscCol129921_1667.
DR EchoBASE; EB2785; -.
DR EcoGene; EG12951; ynfM.
DR eggNOG; ENOG4105D94; Bacteria.
DR eggNOG; ENOG410XP8J; LUCA.
DR HOGENOM; HOG000217197; -.
DR InParanoid; P43531; -.
DR KO; K08224; -.
DR OMA; NFRLHWH; -.
DR PhylomeDB; P43531; -.
DR BioCyc; EcoCyc:B1596-MONOMER; -.
DR PRO; PR:P43531; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0005215; F:transporter activity; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06174; MFS; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Complete proteome; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1 417 Inner membrane transport protein YnfM.
FT /FTId=PRO_0000173411.
FT TOPO_DOM 1 38 Periplasmic. {ECO:0000255}.
FT TRANSMEM 39 59 Helical. {ECO:0000255}.
FT TOPO_DOM 60 73 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 74 94 Helical. {ECO:0000255}.
FT TOPO_DOM 95 101 Periplasmic. {ECO:0000255}.
FT TRANSMEM 102 122 Helical. {ECO:0000255}.
FT TOPO_DOM 123 125 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 126 146 Helical. {ECO:0000255}.
FT TOPO_DOM 147 152 Periplasmic. {ECO:0000255}.
FT TRANSMEM 153 173 Helical. {ECO:0000255}.
FT TOPO_DOM 174 190 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 191 211 Helical. {ECO:0000255}.
FT TOPO_DOM 212 241 Periplasmic. {ECO:0000255}.
FT TRANSMEM 242 262 Helical. {ECO:0000255}.
FT TOPO_DOM 263 264 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 265 285 Helical. {ECO:0000255}.
FT TOPO_DOM 286 315 Periplasmic. {ECO:0000255}.
FT TRANSMEM 316 336 Helical. {ECO:0000255}.
FT TOPO_DOM 337 364 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 365 385 Helical. {ECO:0000255}.
FT TOPO_DOM 386 387 Periplasmic. {ECO:0000255}.
FT TRANSMEM 388 408 Helical. {ECO:0000255}.
FT TOPO_DOM 409 417 Cytoplasmic. {ECO:0000255}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 41 260 ipfam:MFS_1 [T]
FT MYHIT 91 107 ipat:SUGAR_TRANSPORT_1 [T]
FT MYHIT 33 416 iprf:MFS [T]
SQ SEQUENCE 417 AA; 45258 MW; 78862FD89AD1987B CRC64;
MSRTTTVDGA PASDTDKQSI SQPNQFIKRG TPQFMRVTLA LFSAGLATFA LLYCVQPILP
VLSQEFGLTP ANSSISLSIS TAMLAIGLLF TGPLSDAIGR KPVMVTALLL ASICTLLSTM
MTSWHGILIM RALIGLSLSG VAAVGMTYLS EEIHPSFVAF SMGLYISGNS IGGMSGRLIS
GVFTDFFNWR IALAAIGCFA LASALMFWKI LPESRHFRPT SLRPKTLFIN FRLHWRDRGL
PLLFAEGFLL MGSFVTLFNY IGYRLMLSPW HVSQAVVGLL SLAYLTGTWS SPKAGTMTTR
YGRGPVMLFS TGVMLFGLLM TLFSSLWLIF AGMLLFSAGF FAAHSVASSW IGPRAKRAKG
QASSLYLFSY YLGSSIAGTL GGVFWHNYGW NGVGAFIALM LVIALLVGTR LHRRLHA
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