ID YBAL_ECOLI Reviewed; 558 AA.
AC P39830; P52068; P77724; Q2MBU9;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 10-MAY-2017, entry version 145.
DE RecName: Full=Putative cation/proton antiporter YbaL;
GN Name=ybaL; Synonyms=ylaA; OrderedLocusNames=b0478, JW0467;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains
RT MG1655 and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
RC STRAIN=K12 / DH5-alpha;
RA Fujisaki S., Ohnuma S., Horiuchi T., Takahashi I., Tsukui S.,
RA Nishimura Y., Nishino T., Inokuchi H.;
RL Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 486-558.
RC STRAIN=K12;
RX PubMed=7721718; DOI=10.1128/jb.177.8.2236-2240.1995;
RA Harlow K.W., Nygaard P., Hove-Jensen B.;
RT "Cloning and characterization of the gsk gene encoding guanosine
RT kinase of Escherichia coli.";
RL J. Bacteriol. 177:2236-2240(1995).
RN [6]
RP SUBCELLULAR LOCATION, AND TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
RN [7] {ECO:0000244|PDB:3FWZ}
RP X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS) OF 414-550 IN COMPLEX WITH AMP.
RA Chang C., Bigelow L., Buck K., Joachimiak A.;
RT "Crystal structure of TrkA-N domain of inner membrane protein YbaL
RT from Escherichia coli.";
RL Submitted (JAN-2009) to the PDB data bank.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC {ECO:0000305|PubMed:15919996}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2
CC (CPA2) transporter (TC 2.A.37) family. {ECO:0000305}.
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DR EMBL; U82664; AAB40232.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73580.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76257.1; -; Genomic_DNA.
DR EMBL; D73370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; L35149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; E64778; E64778.
DR RefSeq; NP_415011.1; NC_000913.3.
DR RefSeq; WP_000546237.1; NZ_LN832404.1.
DR PDB; 3FWZ; X-ray; 1.79 A; A/B=414-550.
DR PDBsum; 3FWZ; -.
DR ProteinModelPortal; P39830; -.
DR SMR; P39830; -.
DR BioGrid; 4262046; 99.
DR DIP; DIP-11300N; -.
DR IntAct; P39830; 2.
DR MINT; MINT-1293198; -.
DR STRING; 511145.b0478; -.
DR TCDB; 2.A.37.1.5; the monovalent cation:proton antiporter-2 (cpa2) family.
DR PaxDb; P39830; -.
DR PRIDE; P39830; -.
DR EnsemblBacteria; AAC73580; AAC73580; b0478.
DR EnsemblBacteria; BAE76257; BAE76257; BAE76257.
DR GeneID; 946576; -.
DR KEGG; ecj:JW0467; -.
DR KEGG; eco:b0478; -.
DR PATRIC; 32116113; VBIEscCol129921_0498.
DR EchoBASE; EB2507; -.
DR EcoGene; EG12623; ybaL.
DR eggNOG; ENOG4105CKD; Bacteria.
DR eggNOG; COG1226; LUCA.
DR eggNOG; COG4651; LUCA.
DR HOGENOM; HOG000179078; -.
DR InParanoid; P39830; -.
DR KO; K03455; -.
DR OMA; YDDEVSY; -.
DR PhylomeDB; P39830; -.
DR BioCyc; EcoCyc:YBAL-MONOMER; -.
DR EvolutionaryTrace; P39830; -.
DR PRO; PR:P39830; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR004771; K/H_exchanger.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR003148; RCK_N.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR TIGRFAMs; TIGR00932; 2a37; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Antiport; Cell inner membrane; Cell membrane;
KW Complete proteome; Ion transport; Membrane; Nucleotide-binding;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1 558 Putative cation/proton antiporter YbaL.
FT /FTId=PRO_0000196616.
FT TOPO_DOM 1 3 Periplasmic. {ECO:0000255}.
FT TRANSMEM 4 24 Helical. {ECO:0000255}.
FT TOPO_DOM 25 31 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 32 52 Helical. {ECO:0000255}.
FT TOPO_DOM 53 55 Periplasmic. {ECO:0000255}.
FT TRANSMEM 56 76 Helical. {ECO:0000255}.
FT TOPO_DOM 77 85 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 86 106 Helical. {ECO:0000255}.
FT TOPO_DOM 107 112 Periplasmic. {ECO:0000255}.
FT TRANSMEM 113 133 Helical. {ECO:0000255}.
FT TOPO_DOM 134 148 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 149 169 Helical. {ECO:0000255}.
FT TOPO_DOM 170 185 Periplasmic. {ECO:0000255}.
FT TRANSMEM 186 206 Helical. {ECO:0000255}.
FT TOPO_DOM 207 225 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 226 246 Helical. {ECO:0000255}.
FT TOPO_DOM 247 247 Periplasmic. {ECO:0000255}.
FT TRANSMEM 248 268 Helical. {ECO:0000255}.
FT TOPO_DOM 269 279 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 280 300 Helical. {ECO:0000255}.
FT TOPO_DOM 301 303 Periplasmic. {ECO:0000255}.
FT TRANSMEM 304 324 Helical. {ECO:0000255}.
FT TOPO_DOM 325 336 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 337 357 Helical. {ECO:0000255}.
FT TOPO_DOM 358 367 Periplasmic. {ECO:0000255}.
FT TRANSMEM 368 388 Helical. {ECO:0000255}.
FT TOPO_DOM 389 558 Cytoplasmic. {ECO:0000255,
FT ECO:0000269|PubMed:15919996}.
FT DOMAIN 419 541 RCK N-terminal. {ECO:0000255|PROSITE-
FT ProRule:PRU00543}.
FT NP_BIND 427 428 AMP. {ECO:0000244|PDB:3FWZ}.
FT NP_BIND 447 448 AMP. {ECO:0000244|PDB:3FWZ}.
FT NP_BIND 467 468 AMP. {ECO:0000244|PDB:3FWZ}.
FT BINDING 494 494 AMP. {ECO:0000244|PDB:3FWZ}.
FT BINDING 514 514 AMP. {ECO:0000244|PDB:3FWZ}.
FT CONFLICT 553 558 GEVVTG -> VRW (in Ref. 5; L35149).
FT {ECO:0000305}.
FT STRAND 420 423 {ECO:0000244|PDB:3FWZ}.
FT HELIX 427 438 {ECO:0000244|PDB:3FWZ}.
FT STRAND 443 448 {ECO:0000244|PDB:3FWZ}.
FT HELIX 450 458 {ECO:0000244|PDB:3FWZ}.
FT STRAND 462 466 {ECO:0000244|PDB:3FWZ}.
FT HELIX 471 476 {ECO:0000244|PDB:3FWZ}.
FT HELIX 479 481 {ECO:0000244|PDB:3FWZ}.
FT STRAND 483 487 {ECO:0000244|PDB:3FWZ}.
FT HELIX 492 505 {ECO:0000244|PDB:3FWZ}.
FT STRAND 507 517 {ECO:0000244|PDB:3FWZ}.
FT HELIX 518 526 {ECO:0000244|PDB:3FWZ}.
FT STRAND 530 534 {ECO:0000244|PDB:3FWZ}.
FT HELIX 535 548 {ECO:0000244|PDB:3FWZ}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 419 541 iprf:RCK_N [T]
FT MYHIT 13 384 ipfam:Na_H_Exchanger [T]
FT MYHIT 421 534 ipfam:TrkA_N [T]
SQ SEQUENCE 558 AA; 59424 MW; 17DFBAE820B11498 CRC64;
MHHATPLITT IVGGLVLAFI LGMLANKLRI SPLVGYLLAG VLAGPFTPGF VADTKLAPEL
AELGVILLMF GVGLHFSLKD LMAVKAIAIP GAIAQIAVAT LLGMALSAVL GWSLMTGIVF
GLCLSTASTV VLLRALEERQ LIDSQRGQIA IGWLIVEDLV MVLTLVLLPA VAGMMEQGDV
GFATLAVDMG ITIGKVIAFI AIMMLVGRRL VPWIMARSAA TGSRELFTLS VLALALGVAF
GAVELFDVSF ALGAFFAGMV LNESELSHRA AHDTLPLRDA FAVLFFVSVG MLFDPLILIQ
QPLAVLATLA IILFGKSLAA FFLVRLFGHS QRTALTIAAS LAQIGEFAFI LAGLGMALNL
LPQAGQNLVL AGAILSIMLN PVLFALLEKY LAKTETLEEQ TLEEAIEEEK QIPVDICNHA
LLVGYGRVGS LLGEKLLASD IPLVVIETSR TRVDELRERG VRAVLGNAAN EEIMQLAHLE
CAKWLILTIP NGYEAGEIVA SARAKNPDIE IIARAHYDDE VAYITERGAN QVVMGEREIA
RTMLELLETP PAGEVVTG
//
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