ID SUHB_VIBCH Reviewed; 267 AA.
AC Q9KTY5;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 15-MAR-2017, entry version 88.
DE RecName: Full=Inositol-1-monophosphatase;
DE Short=I-1-Pase;
DE Short=IMPase;
DE Short=Inositol-1-phosphatase;
DE EC=3.1.3.25;
GN OrderedLocusNames=VC_0745;
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC Vibrionaceae; Vibrio.
OX NCBI_TaxID=243277;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A.,
RA Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L.,
RA Ermolaeva M.D., Vamathevan J.J., Bass S., Qin H., Dragoi I.,
RA Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D.,
RA Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R.,
RA Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- CATALYTIC ACTIVITY: Myo-inositol phosphate + H(2)O = myo-inositol
CC + phosphate.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the inositol monophosphatase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF93910.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE003852; AAF93910.1; ALT_INIT; Genomic_DNA.
DR PIR; D82285; D82285.
DR RefSeq; NP_230394.2; NC_002505.1.
DR RefSeq; WP_000553435.1; NC_002505.1.
DR ProteinModelPortal; Q9KTY5; -.
DR SMR; Q9KTY5; -.
DR STRING; 243277.VC0745; -.
DR DNASU; 2615754; -.
DR EnsemblBacteria; AAF93910; AAF93910; VC_0745.
DR GeneID; 2615754; -.
DR KEGG; vch:VC0745; -.
DR PATRIC; 20080601; VBIVibCho83274_0709.
DR eggNOG; ENOG4105ECY; Bacteria.
DR eggNOG; COG0483; LUCA.
DR KO; K01092; -.
DR OMA; YDPSRND; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0003824; F:catalytic activity; ISS:TIGR.
DR GO; GO:0008934; F:inositol monophosphate 1-phosphatase activity; IBA:GO_Central.
DR GO; GO:0052832; F:inositol monophosphate 3-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0052833; F:inositol monophosphate 4-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006020; P:inositol metabolic process; IBA:GO_Central.
DR GO; GO:0046855; P:inositol phosphate dephosphorylation; IBA:GO_Central.
DR GO; GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; ISS:TIGR.
DR CDD; cd01639; IMPase; 1.
DR InterPro; IPR033942; IMPase.
DR InterPro; IPR020583; Inositol_monoP_metal-BS.
DR InterPro; IPR000760; Inositol_monophosphatase-like.
DR InterPro; IPR020550; Inositol_monophosphatase_CS.
DR InterPro; IPR022337; Inositol_monophosphatase_SuhB.
DR PANTHER; PTHR20854; PTHR20854; 1.
DR Pfam; PF00459; Inositol_P; 1.
DR PRINTS; PR00377; IMPHPHTASES.
DR PRINTS; PR01959; SBIMPHPHTASE.
DR PROSITE; PS00629; IMP_1; 1.
DR PROSITE; PS00630; IMP_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Hydrolase; Magnesium; Metal-binding;
KW Reference proteome.
FT CHAIN 1 267 Inositol-1-monophosphatase.
FT /FTId=PRO_0000142575.
FT REGION 86 89 Substrate binding. {ECO:0000250}.
FT METAL 67 67 Magnesium 1. {ECO:0000250}.
FT METAL 84 84 Magnesium 1. {ECO:0000250}.
FT METAL 84 84 Magnesium 2. {ECO:0000250}.
FT METAL 86 86 Magnesium 1; via carbonyl oxygen.
FT {ECO:0000250}.
FT METAL 87 87 Magnesium 2. {ECO:0000250}.
FT METAL 212 212 Magnesium 2. {ECO:0000250}.
FT BINDING 67 67 Substrate. {ECO:0000250}.
FT BINDING 183 183 Substrate. {ECO:0000250}.
FT BINDING 212 212 Substrate. {ECO:0000250}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 211 225 ipat:IMP_2 [T]
FT MYHIT 81 94 ipat:IMP_1 [T]
FT MYHIT 2 259 ipfam:Inositol_P [T]
SQ SEQUENCE 267 AA; 29088 MW; 88AD8CDF78A7AD87 CRC64;
MHPMLNIAIR AARKAGNHIA KSLENAEKIQ TTQKGSNDFV TNVDKEAEAI IVSTIKSSYP
EHCIIAEEGG LIEGKDKEVQ WIIDPLDGTT NFVKGFPHFA VSIAVRFRGK TEVACVYDPM
TNELFTAQRG AGAQLNNARI RVQPIKDLQG AVLATAFPFK QKQHSESFMK ILSAMFVECA
DFRRTGSAAL DLCYLAANRV DGYFELGLKP WDMAAGELIA REAGAIVTDF AGGTDYMQSG
NIVASSPRGV KAILQHIREN GNSAILK
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