ID RLUD_BUCAI Reviewed; 312 AA.
AC P57481;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 1.
DT 15-FEB-2017, entry version 88.
DE RecName: Full=Ribosomal large subunit pseudouridine synthase D;
DE EC=5.4.99.23;
DE AltName: Full=23S rRNA pseudouridine(1911/1915/1917) synthase;
DE AltName: Full=rRNA pseudouridylate synthase D;
DE AltName: Full=rRNA-uridine isomerase D;
GN Name=rluD; OrderedLocusNames=BU401;
OS Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)
OS (Acyrthosiphon pisum symbiotic bacterium).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Buchnera.
OX NCBI_TaxID=107806;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=APS;
RX PubMed=10993077; DOI=10.1038/35024074;
RA Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT "Genome sequence of the endocellular bacterial symbiont of aphids
RT Buchnera sp. APS.";
RL Nature 407:81-86(2000).
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil
CC at positions 1911, 1915 and 1917 in 23S ribosomal RNA.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY: 23S rRNA
CC uridine(1911)/uridine(1915)/uridine(1917) = 23S rRNA
CC pseudouridine(1911)/pseudouridine(1915)/pseudouridine(1917).
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000305}.
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DR EMBL; BA000003; BAB13104.1; -; Genomic_DNA.
DR RefSeq; NP_240218.1; NC_002528.1.
DR RefSeq; WP_009874359.1; NC_002528.1.
DR ProteinModelPortal; P57481; -.
DR SMR; P57481; -.
DR STRING; 107806.BU401; -.
DR EnsemblBacteria; BAB13104; BAB13104; BAB13104.
DR GeneID; 1109754; -.
DR KEGG; buc:BU401; -.
DR PATRIC; 21244342; VBIBucAph127364_0415.
DR eggNOG; ENOG4105C34; Bacteria.
DR eggNOG; COG0564; LUCA.
DR HOGENOM; HOG000275919; -.
DR KO; K06180; -.
DR OMA; HDYKWAV; -.
DR Proteomes; UP000001806; Chromosome.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.10.290.10; -; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluD.
DR InterPro; IPR002942; S4_RNA-bd.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55120; SSF55120; 1.
DR TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; Reference proteome; RNA-binding;
KW rRNA processing.
FT CHAIN 1 312 Ribosomal large subunit pseudouridine
FT synthase D.
FT /FTId=PRO_0000162684.
FT DOMAIN 18 87 S4 RNA-binding. {ECO:0000255|PROSITE-
FT ProRule:PRU00182}.
FT ACT_SITE 139 139 {ECO:0000250}.
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CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 135 149 ipat:PSI_RLU [T]
FT MYHIT 18 64 ipfam:S4 [T]
FT MYHIT 18 87 iprf:S4 [T]
FT MYHIT 92 241 ipfam:PseudoU_synth_2 [T]
FT MYHIT 18 76 ismart:S4 [T]
SQ SEQUENCE 312 AA; 35840 MW; 6AC32A7F9260D890 CRC64;
MKKIQLNSIA SSCSLSGQRL DLVLSKLFRE YSRSYLKKLI IMNQVLVNES IVNQPDKKIL
GGETLTIHPF SKDLLVDIPE NIFLDIVYED SDILIINKPA GLVVHPGSGN KSGTILNALL
YHYKNSKDLP RAGIVHRLDK DTSGLMVIAK NIFSYNHLLL LLKEKKIIRE YEGIVHGKMI
AGGTINKPIM RHYNRRTCMM VHHLGKPSVT HYKVLSRFKF HTHIAIRLET GRTHQIRVHM
LHIKYPLVGD PCYSGFKIQS NYRKDKKTNK IYKFPRQALH ANHLSLHHPI KKNVMSWTVP
LPQDIQELLL KI
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