user: GUEST
 width: 600
MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).

Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7

DescriptionRecName: Full=16S rRNA (cytosine(967)-C(5))-methyltransferase {ECO:0000256|SAAS:SAAS00672440}; EC=2.1.1.176 {ECO:0000256|SAAS:SAAS00672440};
MyHits logo
MyHits synonymsQ6MU26_MYCMS , Q6MU26 , 5AE1AE02271E647F
match map segment
iprf:SAM_MT_RSMB_NOP ipfam:Methyltr_RsmB-F ipfam:NusB  
Legends: 1, ACT_SITE Nucleophile. {ECO:0000256|PROSITE- ProRule:PRU01023}; 2, BINDING S-adenosyl-L-methionine. {ECO:0000256|PROSITE-ProRule:PRU01023}. 
ID   Q6MU26_MYCMS            Unreviewed;       432 AA.
AC   Q6MU26;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   10-MAY-2017, entry version 94.
DE   RecName: Full=16S rRNA (cytosine(967)-C(5))-methyltransferase {ECO:0000256|SAAS:SAAS00672440};
DE            EC=2.1.1.176 {ECO:0000256|SAAS:SAAS00672440};
GN   Name=sun {ECO:0000313|EMBL:CAE76860.1};
GN   OrderedLocusNames=MSC_0217 {ECO:0000313|EMBL:CAE76860.1};
OS   Mycoplasma mycoides subsp. mycoides SC (strain PG1).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272632 {ECO:0000313|EMBL:CAE76860.1, ECO:0000313|Proteomes:UP000001016};
RN   [1] {ECO:0000313|EMBL:CAE76860.1, ECO:0000313|Proteomes:UP000001016}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PG1 {ECO:0000313|EMBL:CAE76860.1,
RC   ECO:0000313|Proteomes:UP000001016};
RX   PubMed=14762060; DOI=10.1101/gr.1673304;
RA   Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J.,
RA   Johansson K.-E., Pettersson B., Uhlen M.;
RT   "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type
RT   strain PG1T, the causative agent of contagious bovine pleuropneumonia
RT   (CBPP).";
RL   Genome Res. 14:221-227(2004).
CC   -!- FUNCTION: Specifically methylates the cytosine at position 967
CC       (m5C967) of 16S rRNA. {ECO:0000256|SAAS:SAAS00672432}.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + cytosine(967) in 16S
CC       rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(967) in 16S
CC       rRNA. {ECO:0000256|SAAS:SAAS00672435}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00633808}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. RsmB/NOP family.
CC       {ECO:0000256|PROSITE-ProRule:PRU01023,
CC       ECO:0000256|SAAS:SAAS00811926}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BX293980; CAE76860.1; -; Genomic_DNA.
DR   RefSeq; NP_975218.1; NC_005364.2.
DR   RefSeq; WP_011166417.1; NC_005364.2.
DR   ProteinModelPortal; Q6MU26; -.
DR   STRING; 272632.MSC_0217; -.
DR   EnsemblBacteria; CAE76860; CAE76860; MSC_0217.
DR   GeneID; 2744338; -.
DR   KEGG; mmy:MSC_0217; -.
DR   PATRIC; 20017150; VBIMycMyc4973_0231.
DR   eggNOG; ENOG4105CYJ; Bacteria.
DR   eggNOG; COG0144; LUCA.
DR   HOGENOM; HOG000037300; -.
DR   KO; K03500; -.
DR   OMA; NDCLIAN; -.
DR   Proteomes; UP000001016; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008649; F:rRNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.940.10; -; 1.
DR   InterPro; IPR001678; MeTrfase_RsmB/NOP2.
DR   InterPro; IPR006027; NusB_RsmB_TIM44.
DR   InterPro; IPR023267; RCMT.
DR   InterPro; IPR004573; rRNA_ssu_MeTfrase_B.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   Pfam; PF01189; Methyltr_RsmB-F; 1.
DR   Pfam; PF01029; NusB; 1.
DR   PRINTS; PR02008; RCMTFAMILY.
DR   SUPFAM; SSF48013; SSF48013; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00563; rsmB; 1.
DR   PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001016};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00633812};
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01023,
KW   ECO:0000256|SAAS:SAAS00811925, ECO:0000313|EMBL:CAE76860.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001016};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU01023,
KW   ECO:0000256|SAAS:SAAS00811931};
KW   rRNA processing {ECO:0000256|SAAS:SAAS00633795};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01023,
KW   ECO:0000256|SAAS:SAAS00811929};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU01023,
KW   ECO:0000256|SAAS:SAAS00811925, ECO:0000313|EMBL:CAE76860.1}.
FT   DOMAIN      160    432       SAM_MT_RSMB_NOP.
FT                                {ECO:0000259|PROSITE:PS51686}.
FT   ACT_SITE    380    380       Nucleophile. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01023}.
FT   BINDING     284    284       S-adenosyl-L-methionine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01023}.
FT   BINDING     311    311       S-adenosyl-L-methionine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01023}.
FT   BINDING     327    327       S-adenosyl-L-methionine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       160    432       iprf:SAM_MT_RSMB_NOP [T]
FT   MYHIT       246    414       ipfam:Methyltr_RsmB-F [T]
FT   MYHIT        10    131       ipfam:NusB [T]
SQ   SEQUENCE   432 AA;  50244 MW;  5AE1AE02271E647F CRC64;
     MLNKNIIITM NSRYIAFDIL KKVFVNKAYS NVLLNKISKK DLNQQTKDFI FNLVHGVISN
     KIHLDYLLTK LIDVKKTSID LQIILLISLY QMIYLNSIPN YAIVNESVNL IKTTSQKQAN
     FINAILNKFL RFKDTYLEIN LDNKDLELCI LHSFSYELYL MLIKQYDKDI VNQIVVNNHQ
     IPKLYIRLNT LKITSDQLFN KYKDIYLLKK TNVNDCLIAN KTIINSNLYK NGFITIQDKA
     SILVSQILNP SLNTKVLDMC SAPGGKLTHL SMILKNTGNI IGNEINESKI KLIKENINRL
     NCLNISLTNM DARKIKQKEE FDYVLLDAPC SGFGVFKRKP EIKLRFDQVQ VNSIINLQEE
     LLESAYYNLK NNGEMVYSTC TINQDENQNQ ITKFLNRHED MVKLYEKQIF GFEENTDGFY
     ICKLKKLKEN HE
//