ID FHUB_BACSU Reviewed; 384 AA.
AC P49936;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 10-MAY-2017, entry version 111.
DE RecName: Full=Iron(3+)-hydroxamate import system permease protein FhuB;
DE AltName: Full=Ferric hydroxamate uptake protein B;
DE AltName: Full=Ferrichrome transport system permease protein FhuB;
DE AltName: Full=Iron(III)-hydroxamate import system permease protein FhuB;
GN Name=fhuB; OrderedLocusNames=BSU33310;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Schneider R., Hantke K.;
RL Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9639930; DOI=10.1099/00221287-144-6-1593;
RA Wipat A., Brignell C.S., Guy J.B., Rose M., Emmerson P.T.,
RA Harwood C.R.;
RT "The yvsA-yvqA (293 degrees - 289 degrees) region of the Bacillus
RT subtilis chromosome containing genes involved in metal ion uptake and
RT a putative sigma factor.";
RL Microbiology 144:1593-1600(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G.,
RA Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S.,
RA Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S.,
RA Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M.,
RA Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A.,
RA Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T.,
RA Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D.,
RA Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N.,
RA Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G.,
RA Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A.,
RA Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M.,
RA Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M.,
RA Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S.,
RA Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G.,
RA Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B.,
RA Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R.,
RA Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P.,
RA Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H.,
RA Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P.,
RA Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F.,
RA Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H.,
RA Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-38.
RC STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 /
RC NCIMB 3610 / VKM B-501;
RX PubMed=8388528; DOI=10.1111/j.1365-2958.1993.tb01208.x;
RA Schneider R., Hantke K.;
RT "Iron-hydroxamate uptake systems in Bacillus subtilis: identification
RT of a lipoprotein as part of a binding protein-dependent transport
RT system.";
RL Mol. Microbiol. 8:111-121(1993).
CC -!- FUNCTION: Part of the ABC transporter complex FhuBGCD involved in
CC iron(3+)-hydroxamate import. Responsible for the translocation of
CC the substrate across the membrane (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The complex is composed of an ATP-binding protein (FhuC),
CC two transmembrane proteins (FhuB and FhuG) and a solute-binding
CC protein (FhuD or YxeB). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport
CC system permease family. FecCD subfamily. {ECO:0000305}.
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DR EMBL; X93092; CAA63643.1; -; Genomic_DNA.
DR EMBL; AJ223978; CAA11720.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15337.1; -; Genomic_DNA.
DR EMBL; M87283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; A69622; A69622.
DR RefSeq; NP_391212.1; NC_000964.3.
DR RefSeq; WP_010886613.1; NZ_CP019663.1.
DR ProteinModelPortal; P49936; -.
DR SMR; P49936; -.
DR STRING; 224308.Bsubs1_010100018086; -.
DR PaxDb; P49936; -.
DR PRIDE; P49936; -.
DR EnsemblBacteria; CAB15337; CAB15337; BSU33310.
DR GeneID; 937085; -.
DR KEGG; bsu:BSU33310; -.
DR PATRIC; 18978660; VBIBacSub10457_3493.
DR eggNOG; ENOG4105DQ5; Bacteria.
DR eggNOG; COG0609; LUCA.
DR HOGENOM; HOG000045410; -.
DR InParanoid; P49936; -.
DR KO; K02015; -.
DR OMA; KWQSINM; -.
DR PhylomeDB; P49936; -.
DR BioCyc; BSUB:BSU33310-MONOMER; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005215; F:transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR InterPro; IPR029022; ABC_BtuC-like.
DR InterPro; IPR000522; ABC_transptr_FecCD.
DR PANTHER; PTHR30472; PTHR30472; 1.
DR Pfam; PF01032; FecCD; 1.
DR SUPFAM; SSF81345; SSF81345; 1.
PE 3: Inferred from homology;
KW Cell membrane; Complete proteome; Ion transport; Iron; Iron transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1 384 Iron(3+)-hydroxamate import system
FT permease protein FhuB.
FT /FTId=PRO_0000060026.
FT TRANSMEM 58 78 Helical. {ECO:0000255}.
FT TRANSMEM 115 135 Helical. {ECO:0000255}.
FT TRANSMEM 154 174 Helical. {ECO:0000255}.
FT TRANSMEM 176 196 Helical. {ECO:0000255}.
FT TRANSMEM 202 222 Helical. {ECO:0000255}.
FT TRANSMEM 243 263 Helical. {ECO:0000255}.
FT TRANSMEM 296 316 Helical. {ECO:0000255}.
FT TRANSMEM 330 350 Helical. {ECO:0000255}.
FT TRANSMEM 357 377 Helical. {ECO:0000255}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 70 379 ipfam:FecCD [T]
SQ SEQUENCE 384 AA; 40720 MW; 7E4D75CAB36AB8FB CRC64;
MHFHFCSKHS IKSAEKSDIL KQQLIIIISN RKEVRQLSQH KNIRTASEEI QWTSRTYGAV
IVLIAGLCLL CLGAFLSISL GAADIHLRTV WEAIFHYQPT KTSHQIIHDL RLPRTAAAAL
VGALLAVSGA IMQGMTRNPL AEPSIMGVTS GSAFAVSIAF AFFPGLSAMG LVLWSFAGAG
LGASTVMGIG MFSRGGLTPV KLALAGTAVT YFFTGISTAI AIRFDVAQDI SFWYAGGVAG
VKWSGVQLLL IAGAVGLTLA FFIARSVTVL SLGDDLAKGL GQYTSAVKLV GMLIVVILTG
AAVSIAGTIA FIGLIIPHIT RFLVGVDYRW IIPCSAVLGA VLLVFADIAA RLVNAPFETP
VGALTSLIGV PFFFYLARRE RRGL
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