MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=Ferric enterobactin transport protein FepE; |
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| MyHits synonyms | FEPE_ECOLI , P26266 , Q2MBL4 , 1C81D51BBFC3A499 |
 Legends: 1, TOPO_DOM Cytoplasmic. {ECO:0000255}; 2, TRANSMEM Helical. {ECO:0000255}.
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ID FEPE_ECOLI Reviewed; 377 AA.
AC P26266; Q2MBL4;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 2.
DT 15-FEB-2017, entry version 121.
DE RecName: Full=Ferric enterobactin transport protein FepE;
GN Name=fepE; OrderedLocusNames=b0587, JW0579;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RA Shea Cleavinger C.M., Ozenberger B., McIntosh M.;
RL Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains
RT MG1655 and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-89.
RC STRAIN=K12;
RX PubMed=1826089; DOI=10.1021/bi00225a027;
RA Rusnak F., Sakaitani M., Drueckhammer D., Reichert J., Walsh C.T.;
RT "Biosynthesis of the Escherichia coli siderophore enterobactin:
RT sequence of the entF gene, expression and purification of EntF, and
RT analysis of covalent phosphopantetheine.";
RL Biochemistry 30:2916-2927(1991).
RN [6]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
RN [7]
RP OPERON STRUCTURE, AND INDUCTION.
RC STRAIN=K12 / BW25113;
RX PubMed=19429622; DOI=10.1128/JB.00108-09;
RA Shimada T., Yamamoto K., Ishihama A.;
RT "Involvement of the leucine response transcription factor LeuO in
RT regulation of the genes for sulfa drug efflux.";
RL J. Bacteriol. 191:4562-4571(2009).
CC -!- FUNCTION: Part of the ferric enterobactin transport system.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC protein.
CC -!- INDUCTION: Repressed by H-NS, induced by LeuO. A monocistronic
CC operon. {ECO:0000269|PubMed:19429622}.
CC -!- SIMILARITY: Belongs to the WzzB/Cld/Rol family. {ECO:0000305}.
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DR EMBL; X74129; CAA52226.1; -; Genomic_DNA.
DR EMBL; U82598; AAB40786.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73688.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76342.1; -; Genomic_DNA.
DR EMBL; M60177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; S34703; S34703.
DR RefSeq; NP_415119.1; NC_000913.3.
DR RefSeq; WP_000096692.1; NZ_LN832404.1.
DR ProteinModelPortal; P26266; -.
DR SMR; P26266; -.
DR BioGrid; 4259898; 146.
DR DIP; DIP-9596N; -.
DR IntAct; P26266; 9.
DR STRING; 511145.b0587; -.
DR PaxDb; P26266; -.
DR PRIDE; P26266; -.
DR EnsemblBacteria; AAC73688; AAC73688; b0587.
DR EnsemblBacteria; BAE76342; BAE76342; BAE76342.
DR GeneID; 945180; -.
DR KEGG; ecj:JW0579; -.
DR KEGG; eco:b0587; -.
DR PATRIC; 32116350; VBIEscCol129921_0615.
DR EchoBASE; EB0293; -.
DR EcoGene; EG10297; fepE.
DR eggNOG; ENOG4108QY5; Bacteria.
DR eggNOG; COG3765; LUCA.
DR HOGENOM; HOG000117856; -.
DR InParanoid; P26266; -.
DR OMA; RKQDAVM; -.
DR PhylomeDB; P26266; -.
DR BioCyc; EcoCyc:EG10297-MONOMER; -.
DR PRO; PR:P26266; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015620; F:ferric-enterobactin transmembrane transporter activity; IMP:EcoCyc.
DR GO; GO:0015685; P:ferric-enterobactin transport; IMP:EcoCyc.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR InterPro; IPR003856; LipoPS_biosynth.
DR Pfam; PF02706; Wzz; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Complete proteome; Ion transport;
KW Iron; Iron transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 377 Ferric enterobactin transport protein
FT FepE.
FT /FTId=PRO_0000087225.
FT TOPO_DOM 1 41 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 42 62 Helical. {ECO:0000255}.
FT TOPO_DOM 63 338 Periplasmic. {ECO:0000255}.
FT TRANSMEM 339 359 Helical. {ECO:0000255}.
FT TOPO_DOM 360 377 Cytoplasmic. {ECO:0000255}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 25 122 ipfam:Wzz [T]
SQ SEQUENCE 377 AA; 42100 MW; 1C81D51BBFC3A499 CRC64;
MSSLNIKQGS DAHFPDYPLA SPSNNEIDLL NLISVLWRAK KTVMAVVFAF ACAGLLISFI
LPQKWTSAAV VTPPEPVQWQ ELEKSFTKLR VLDLDIKIDR TEAFNLFIKK FQSVSLLEEY
LRSSPYVMDQ LKEAKIDELD LHRAIVALSE KMKAVDDNAS KKKDEPSLYT SWTLSFTAPT
SEEAQTVLSG YIDYISTLVV KESLENVRNK LEIKTQFEKE KLAQDRIKTK NQLDANIQRL
NYSLDIANAA GIKKPVYSNG QAVKDDPDFS ISLGADGIER KLEIEKAVTD VAELNGELRN
RQYLVEQLTK AHVNDVNFTP FKYQLSPSLP VKKDGPGKAI IVILSALIGG MVACGGVLLR
YAMASRKQDA MMADHLV
//
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