ID FADR_KLEP7 Reviewed; 239 AA.
AC A6TAW6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 15-MAR-2017, entry version 63.
DE RecName: Full=Fatty acid metabolism regulator protein {ECO:0000255|HAMAP-Rule:MF_00696};
GN Name=fadR {ECO:0000255|HAMAP-Rule:MF_00696};
GN OrderedLocusNames=KPN78578_22760; ORFNames=KPN_02311;
OS Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH
OS 78578).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella.
OX NCBI_TaxID=272620;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700721 / MGH 78578;
RG The Klebsiella pneumonia Genome Sequencing Project;
RA McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Multifunctional regulator of fatty acid metabolism.
CC {ECO:0000255|HAMAP-Rule:MF_00696}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00696}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00696}.
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DR EMBL; CP000647; ABR77737.1; -; Genomic_DNA.
DR RefSeq; WP_002910890.1; NC_009648.1.
DR ProteinModelPortal; A6TAW6; -.
DR SMR; A6TAW6; -.
DR STRING; 272620.KPN_02311; -.
DR EnsemblBacteria; ABR77737; ABR77737; KPN_02311.
DR KEGG; kpn:KPN_02311; -.
DR PATRIC; 20458910; VBIKlePne13394_2338.
DR eggNOG; ENOG4105C05; Bacteria.
DR eggNOG; COG2186; LUCA.
DR HOGENOM; HOG000278467; -.
DR KO; K03603; -.
DR OMA; IWETSGL; -.
DR Proteomes; UP000000265; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0019217; P:regulation of fatty acid metabolic process; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.20.120.530; -; 1.
DR HAMAP; MF_00696; HTH_FadR; 1.
DR InterPro; IPR014178; FA-response_TF_FadR.
DR InterPro; IPR028374; FadR_C.
DR InterPro; IPR008920; TF_FadR/GntR_C.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF07840; FadR_C; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF48008; SSF48008; 1.
DR TIGRFAMs; TIGR02812; fadR_gamma; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Activator; Complete proteome; Cytoplasm; DNA-binding;
KW Fatty acid metabolism; Lipid metabolism; Reference proteome;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1 239 Fatty acid metabolism regulator protein.
FT /FTId=PRO_1000045463.
FT DOMAIN 6 74 HTH gntR-type. {ECO:0000255|HAMAP-
FT Rule:MF_00696}.
FT DNA_BIND 34 53 H-T-H motif. {ECO:0000255|HAMAP-
FT Rule:MF_00696}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 12 71 ismart:HTH_GNTR [T]
FT MYHIT 1 239 ihamap:HTH_FadR [T]
FT MYHIT 6 74 iprf:HTH_GNTR [T]
FT MYHIT 11 71 ipfam:GntR [T]
FT MYHIT 72 234 ipfam:FadR_C [T]
SQ SEQUENCE 239 AA; 27089 MW; D8BF4E8AF1742534 CRC64;
MVIKAQSPAG FAEEYIIESI WNNRFPPGSI LPAERELSEL IGVTRTTLRE VLQRLARDGW
LTIQHGKPTK VNNFWETSGL NILETLARLD HDSVPQLIDN LLSVRTNIST IFIRTAFRQH
PDKALAVLDS AREVEDHADA FAELDYNIFR GLAFASGNPI YGLILNGMKG LYTRIGRHYF
SSPEARSLAL GFYHQLAKVC EAGLHDQVYE LVRRYGHDSG EIWHRMQKSL PGDLAMNMR
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