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Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7

DescriptionSubName: Full=16S rRNA m(5)C 967 methyltransferase {ECO:0000313|EMBL:CCC78930.1}; EC=2.1.1.- {ECO:0000313|EMBL:CCC78930.1};
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MyHits synonymsF9UNZ1_LACPL , F9UNZ1 , BBC9C9F4021A2545
match map segment
ipfam:Methyltr_RsmB-F ipfam:NusB iprf:SAM_MT_RSMB_NOP ipat:NOL1_NOP2_SUN  
Legends: 1, ACT_SITE Nucleophile. {ECO:0000256|PROSITE- ProRule:PRU01023}; 2, BINDING S-adenosyl-L-methionine. {ECO:0000256|PROSITE-ProRule:PRU01023}; 3, ipat:NOL1_NOP2_SUN [T]. 
ID   F9UNZ1_LACPL            Unreviewed;       447 AA.
AC   F9UNZ1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   10-MAY-2017, entry version 44.
DE   SubName: Full=16S rRNA m(5)C 967 methyltransferase {ECO:0000313|EMBL:CCC78930.1};
DE            EC=2.1.1.- {ECO:0000313|EMBL:CCC78930.1};
GN   Name=sunL {ECO:0000313|EMBL:CCC78930.1};
GN   OrderedLocusNames=lp_1617 {ECO:0000313|EMBL:CCC78930.1};
OS   Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=220668 {ECO:0000313|EMBL:CCC78930.1, ECO:0000313|Proteomes:UP000000432};
RN   [1] {ECO:0000313|EMBL:CCC78930.1, ECO:0000313|Proteomes:UP000000432}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1
RC   {ECO:0000313|Proteomes:UP000000432};
RX   PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA   Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D.,
RA   Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M.,
RA   Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A.,
RA   Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B.,
RA   De Vos W.M., Siezen R.J.;
RT   "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=WCFS1;
RA   Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA   Kleerebezem M., van Hijum S.A.F.T.;
RT   "Complete resequencing and reannotation of the Lactobacillus plantarum
RT   WCFS1 genome.";
RL   Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specifically methylates the cytosine at position 967
CC       (m5C967) of 16S rRNA. {ECO:0000256|SAAS:SAAS00672432}.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + cytosine(967) in 16S
CC       rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(967) in 16S
CC       rRNA. {ECO:0000256|SAAS:SAAS00672435}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00633808}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. RsmB/NOP family.
CC       {ECO:0000256|PROSITE-ProRule:PRU01023,
CC       ECO:0000256|SAAS:SAAS00637407}.
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DR   EMBL; AL935263; CCC78930.1; -; Genomic_DNA.
DR   RefSeq; WP_011101476.1; NC_004567.2.
DR   RefSeq; YP_004889444.1; NC_004567.2.
DR   ProteinModelPortal; F9UNZ1; -.
DR   STRING; 220668.lp_1617; -.
DR   EnsemblBacteria; CCC78930; CCC78930; lp_1617.
DR   GeneID; 1063708; -.
DR   KEGG; lpl:lp_1617; -.
DR   eggNOG; ENOG4105CYJ; Bacteria.
DR   eggNOG; COG0144; LUCA.
DR   KO; K03500; -.
DR   OMA; HIGLYQL; -.
DR   BioCyc; LPLA220668:G137Z-1386-MONOMER; -.
DR   Proteomes; UP000000432; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008649; F:rRNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.940.10; -; 1.
DR   InterPro; IPR018314; Fmu/NOL1/Nop2p_CS.
DR   InterPro; IPR001678; MeTrfase_RsmB/NOP2.
DR   InterPro; IPR006027; NusB_RsmB_TIM44.
DR   InterPro; IPR023267; RCMT.
DR   InterPro; IPR004573; rRNA_ssu_MeTfrase_B.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   Pfam; PF01189; Methyltr_RsmB-F; 1.
DR   Pfam; PF01029; NusB; 1.
DR   PRINTS; PR02008; RCMTFAMILY.
DR   SUPFAM; SSF48013; SSF48013; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00563; rsmB; 1.
DR   PROSITE; PS01153; NOL1_NOP2_SUN; 1.
DR   PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000432};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00633812};
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01023,
KW   ECO:0000256|SAAS:SAAS00637415, ECO:0000313|EMBL:CCC78930.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000432};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU01023,
KW   ECO:0000256|SAAS:SAAS00637422};
KW   rRNA processing {ECO:0000256|SAAS:SAAS00633795};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01023,
KW   ECO:0000256|SAAS:SAAS00637399};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU01023,
KW   ECO:0000256|SAAS:SAAS00637415, ECO:0000313|EMBL:CCC78930.1}.
FT   DOMAIN      171    447       SAM_MT_RSMB_NOP.
FT                                {ECO:0000259|PROSITE:PS51686}.
FT   ACT_SITE    386    386       Nucleophile. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01023}.
FT   BINDING     286    286       S-adenosyl-L-methionine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01023}.
FT   BINDING     314    314       S-adenosyl-L-methionine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01023}.
FT   BINDING     333    333       S-adenosyl-L-methionine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       247    445       ipfam:Methyltr_RsmB-F [T]
FT   MYHIT         8    129       ipfam:NusB [T]
FT   MYHIT       171    447       iprf:SAM_MT_RSMB_NOP [T]
FT   MYHIT       327    338       ipat:NOL1_NOP2_SUN [T]
SQ   SEQUENCE   447 AA;  50117 MW;  BBC9C9F4021A2545 CRC64;
     MSTVGNTPRW LAVAALAKIK NGAYSNLQLN QLINDHQMDR RDINLLTNMV YGVIQHRLTL
     EYWLTPFVRH PHQIDPWVRE LLLSALYQWQ YLDKIPQRAV FNETIEIAKV KGHPGIRRFV
     TGVLHQMDRS GLPSFDAIKN PDERLSVTYS MPIWLIQELR RQLGAEKMER ILSSLNQPAK
     QALRVNPALS TVEDVTTALI NDGLTITPSE ISPLGLIATD GQAINTEAMR YGMFTVQDES
     AQLVVPALNP QPNDRVLDAC AAPGGKTTQI AASLDAEQGG TVVALDIHAN KVKLIGQNAA
     RMHVADRVEA TELDARKVET QFNAESFDRI LVDAPCSGLG LMRRKPEIRY EKQLQDSLNL
     QRIQLAILTA VAPTLKKGGI MTYSTCTILQ QENQDVITKF LADHPDFELQ TTPTERDLKT
     DRTEKTLSIY PDDYLSDGFF IACLRKK
//