MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=Copper-exporting P-type ATPase A; EC=3.6.3.54; AltName: Full=Cu(+)-exporting ATPase; |
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| MyHits synonyms | COPA_YERPE , Q8ZCA7 , Q0WCI2 , 8FE8B194BF356A33 |
 Legends: 1, ACT_SITE 4-aspartylphosphate intermediate. {ECO:0000305}; 2, Copper. {ECO:0000255|PROSITE- ProRule:PRU00280}; 3, Magnesium. {ECO:0000255|PROSITE- ProRule:PRU00280}; 4, CONFLICT R -> S (in Ref. 2; AAM84670 and 3; AAS61097). {ECO:0000305}; 5, TRANSMEM Helical. {ECO:0000255}; 6, HMA 1. {ECO:0000255|PROSITE- ProRule:PRU00280}; 7, HMA 2. {ECO:0000255|PROSITE- ProRule:PRU00280}; 8, HMA 3. {ECO:0000255|PROSITE- ProRule:PRU00280}; 9, iprf:HMA_2 [T]; 10, ipat:HMA_1 [T]; 11, ipfam:HMA [T]; 12, ipat:ATPASE_E1_E2 [T].
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ID COPA_YERPE Reviewed; 961 AA.
AC Q8ZCA7; Q0WCI2;
DT 03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 10-MAY-2017, entry version 134.
DE RecName: Full=Copper-exporting P-type ATPase A;
DE EC=3.6.3.54;
DE AltName: Full=Cu(+)-exporting ATPase;
GN Name=copA; OrderedLocusNames=YPO3086, y1093, YP_0838;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G.,
RA Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V.,
RA Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M.,
RA Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/JB.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C.,
RA Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V.,
RA Straley S.C., McDonough K.A., Nilles M.L., Matson J.S., Blattner F.R.,
RA Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z.,
RA Jin L., Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J.,
RA Yang H., Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Involved in copper export. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY: ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate
CC + Cu(+)(Side 2).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type)
CC (TC 3.A.3) family. Type IB subfamily. {ECO:0000305}.
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DR EMBL; AL590842; CAL21688.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84670.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS61097.1; -; Genomic_DNA.
DR PIR; AE0375; AE0375.
DR RefSeq; WP_002208579.1; NZ_LIXY01000015.1.
DR RefSeq; YP_002348006.1; NC_003143.1.
DR ProteinModelPortal; Q8ZCA7; -.
DR SMR; Q8ZCA7; -.
DR STRING; 187410.y1093; -.
DR PRIDE; Q8ZCA7; -.
DR DNASU; 1146039; -.
DR EnsemblBacteria; AAM84670; AAM84670; y1093.
DR EnsemblBacteria; AAS61097; AAS61097; YP_0838.
DR GeneID; 1175907; -.
DR KEGG; ype:YPO3086; -.
DR KEGG; ypk:y1093; -.
DR KEGG; ypl:CH46_2014; -.
DR KEGG; ypm:YP_0838; -.
DR KEGG; ypv:BZ15_442; -.
DR KEGG; ypw:CH59_2980; -.
DR eggNOG; ENOG4105C59; Bacteria.
DR eggNOG; COG2217; LUCA.
DR HOGENOM; HOG000250397; -.
DR KO; K17686; -.
DR OMA; FRANAIG; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019829; F:cation-transporting ATPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 3.
DR Gene3D; 1.20.1110.10; -; 1.
DR Gene3D; 3.40.1110.10; -; 1.
DR Gene3D; 3.40.50.1000; -; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_domN.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A.
DR InterPro; IPR023214; HAD-like_dom.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 3.
DR SUPFAM; SSF55008; SSF55008; 3.
DR SUPFAM; SSF56784; SSF56784; 2.
DR TIGRFAMs; TIGR01525; ATPase-IB_hvy; 1.
DR TIGRFAMs; TIGR01494; ATPase_P-type; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 3.
DR PROSITE; PS50846; HMA_2; 3.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Complete proteome; Copper;
KW Copper transport; Hydrolase; Ion transport; Magnesium; Membrane;
KW Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1 961 Copper-exporting P-type ATPase A.
FT /FTId=PRO_0000046325.
FT TRANSMEM 316 336 Helical. {ECO:0000255}.
FT TRANSMEM 345 365 Helical. {ECO:0000255}.
FT TRANSMEM 381 401 Helical. {ECO:0000255}.
FT TRANSMEM 565 585 Helical. {ECO:0000255}.
FT TRANSMEM 592 612 Helical. {ECO:0000255}.
FT TRANSMEM 860 880 Helical. {ECO:0000255}.
FT TRANSMEM 906 926 Helical. {ECO:0000255}.
FT TRANSMEM 928 948 Helical. {ECO:0000255}.
FT DOMAIN 4 65 HMA 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00280}.
FT DOMAIN 70 131 HMA 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00280}.
FT DOMAIN 227 290 HMA 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00280}.
FT ACT_SITE 650 650 4-aspartylphosphate intermediate.
FT {ECO:0000305}.
FT METAL 14 14 Copper. {ECO:0000255|PROSITE-
FT ProRule:PRU00280}.
FT METAL 17 17 Copper. {ECO:0000255|PROSITE-
FT ProRule:PRU00280}.
FT METAL 80 80 Copper. {ECO:0000255|PROSITE-
FT ProRule:PRU00280}.
FT METAL 83 83 Copper. {ECO:0000255|PROSITE-
FT ProRule:PRU00280}.
FT METAL 237 237 Copper. {ECO:0000255|PROSITE-
FT ProRule:PRU00280}.
FT METAL 240 240 Copper. {ECO:0000255|PROSITE-
FT ProRule:PRU00280}.
FT METAL 847 847 Magnesium. {ECO:0000255|PROSITE-
FT ProRule:PRU00280}.
FT METAL 851 851 Magnesium. {ECO:0000255|PROSITE-
FT ProRule:PRU00280}.
FT CONFLICT 376 376 R -> S (in Ref. 2; AAM84670 and 3;
FT AAS61097). {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 70 131 iprf:HMA_2 [T]
FT MYHIT 4 65 iprf:HMA_2 [T]
FT MYHIT 75 104 ipat:HMA_1 [T]
FT MYHIT 9 38 ipat:HMA_1 [T]
FT MYHIT 227 290 iprf:HMA_2 [T]
FT MYHIT 234 286 ipfam:HMA [T]
FT MYHIT 650 656 ipat:ATPASE_E1_E2 [T]
FT MYHIT 74 128 ipfam:HMA [T]
FT MYHIT 232 261 ipat:HMA_1 [T]
FT MYHIT 8 62 ipfam:HMA [T]
SQ SEQUENCE 961 AA; 101409 MW; 8FE8B194BF356A33 CRC64;
MLQTTLLALQ GLSCMNCAQR VKAALESRED VHHAEVNVHY AKVTGEADTH ALIETIKQTG
YQATEAQTPD VELHLSGLSC GHCTETVRKA LEAVSGVISA DVTLESANVY GKADIQTLIA
AVEQAGYHAT QQGIDSPKTE PLTHSAQSQP ESLAAAPNTV PATNVALATS TVSDTNTVLP
TNTALPTNTT STTSTADTAS ATSTAPVINP LPVTESVAQP AASEGESVQL LLTGMSCASC
VSKVQNALQR VDGVQVARVN LAERSALVTG TQNNEALIAA VKNAGYGAEI IEDEGERRER
QQQMSQASMK RFQWQAALGL LLGIPLMAWG LFGGSMTLTP ETQTPWLIIG IITLLVMIFA
GGHFYRNAWV SLKNGRATMD TLVALGTGAA WIYSITVNIW PDVFPMEARH LYYEASAMII
GLINLGHAME QRARQRSSNA LERLLDLAPP TAKLVTDDGE KVIPLADVQL GMILRLTTGD
RVPVDGEIVQ GEVWMDEAML TGEPIPQQKS VGDIVHAGTQ VQDGTVQFRA SAIGSQTTLA
RIIKLVRQAQ SSKPEIGKLA DRISAVFVPT VVVIAIVAGL IWYFFGPQPQ LVYTLVVATT
VLIIACPCAL GLATPMSIIS GVGRAAEFGV LVRDADALQQ ASNLDTLVFD KTGTLTEGHP
QVVAIHTFNG VSEQQALGWA AALETGSNHP LARAILQRAE GLTLATASQF RTLRGLGVSG
EVDGIPLLLG NNRLLEEQQI DTRELQSLIQ QQAESGATPV ILTANGKPAA LLSIRDPLRE
DSIGALQRLH QLGYSLVMLT GDNPITANAI AKEAGIDRVI AGVLPDGKAD AIKQLQAAGH
KVAMIGDGIN DAPALAQADV GIAMGGGSDI AIETAAITLM RHSLYGVVDA VELSKATLRN
MKQNLLGAFF YNALGIPIAA GILYPFTGTL LSPVVAGAAM ALSSITVVSN ANRLLRFKPK
Q
//
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