ID AMPE_ECOLI Reviewed; 284 AA.
AC P0AE14; P13017;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 15-FEB-2017, entry version 77.
DE RecName: Full=Protein AmpE;
GN Name=ampE; OrderedLocusNames=b0111, JW0107;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=2691840; DOI=10.1111/j.1365-2958.1989.tb00259.x;
RA Lindquist S., Galleni M., Lindberg F., Normark S.;
RT "Signalling proteins in enterobacterial AmpC beta-lactamase
RT regulation.";
RL Mol. Microbiol. 3:1091-1102(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=2607970; DOI=10.1111/j.1365-2958.1989.tb00262.x;
RA Honore N., Nicolas M.H., Cole S.T.;
RT "Regulation of enterobacterial cephalosporinase production: the role
RT of a membrane-bound sensory transducer.";
RL Mol. Microbiol. 3:1121-1130(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains
RT MG1655 and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Putative signaling protein in beta-lactamase regulation.
CC AmpE seems not to act as a direct sensor for beta-lactams.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC protein.
CC -!- INDUCTION: The level of AmpE affects the basal level of beta-
CC lactamase expression in the absence of AmpD and in the presence of
CC the AmpR transcriptional regulator.
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DR EMBL; X15237; CAA33315.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73222.1; -; Genomic_DNA.
DR EMBL; AP009048; BAB96680.1; -; Genomic_DNA.
DR PIR; S05570; S05570.
DR RefSeq; NP_414653.1; NC_000913.3.
DR RefSeq; WP_000172005.1; NZ_LN832404.1.
DR ProteinModelPortal; P0AE14; -.
DR BioGrid; 4259732; 5.
DR DIP; DIP-47964N; -.
DR IntAct; P0AE14; 2.
DR STRING; 511145.b0111; -.
DR TCDB; 9.B.125.1.1; the ampe/cobd (ampe/cobd) family.
DR PaxDb; P0AE14; -.
DR PRIDE; P0AE14; -.
DR EnsemblBacteria; AAC73222; AAC73222; b0111.
DR EnsemblBacteria; BAB96680; BAB96680; BAB96680.
DR GeneID; 946678; -.
DR KEGG; ecj:JW0107; -.
DR KEGG; eco:b0111; -.
DR PATRIC; 32115323; VBIEscCol129921_0113.
DR EchoBASE; EB0040; -.
DR EcoGene; EG10042; ampE.
DR eggNOG; ENOG4106A72; Bacteria.
DR eggNOG; COG3725; LUCA.
DR HOGENOM; HOG000116788; -.
DR KO; K03807; -.
DR OMA; HFSRALP; -.
DR BioCyc; EcoCyc:EG10042-MONOMER; -.
DR PRO; PR:P0AE14; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR InterPro; IPR031347; AmpE.
DR Pfam; PF17113; AmpE; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Complete proteome; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 284 Protein AmpE.
FT /FTId=PRO_0000064592.
FT TOPO_DOM 1 43 Periplasmic. {ECO:0000255}.
FT TRANSMEM 44 60 Helical. {ECO:0000255}.
FT TOPO_DOM 61 67 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 68 84 Helical. {ECO:0000255}.
FT TOPO_DOM 85 194 Periplasmic. {ECO:0000255}.
FT TRANSMEM 195 211 Helical. {ECO:0000255}.
FT TOPO_DOM 212 267 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 268 284 Helical. {ECO:0000255}.
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CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 1 284 ipfam:AmpE [T]
SQ SEQUENCE 284 AA; 32122 MW; C92C05B2DFE0D6AD CRC64;
MTLFTTLLVL IFERLFKLGE HWQLDHRLEA FFRRVKHFSL GRTLGMTIIA MGVTFLLLRA
LQGVLFNVPT LLVWLLIGLL CIGAGKVRLH YHAYLTAASR NDSHARATMA GELTMIHGVP
AGCDEREYLR ELQNALLWIN FRFYLAPLFW LIVGGTWGPV TLMGYAFLRA WQYWLARYQT
PHHRLQSGID AVLHVLDWVP VRLAGVVYAL IGHGEKALPA WFASLGDFHT SQYQVLTRLA
QFSLAREPHV DKVETPKAAV SMAKKTSFVV VVVIALLTIY GALV
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