ID PFDA_HYPBU Reviewed; 154 AA.
AC A2BN59;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 10-MAY-2017, entry version 55.
DE RecName: Full=Prefoldin subunit alpha {ECO:0000255|HAMAP-Rule:MF_00308};
DE AltName: Full=GimC subunit alpha {ECO:0000255|HAMAP-Rule:MF_00308};
GN Name=pfdA {ECO:0000255|HAMAP-Rule:MF_00308};
GN OrderedLocusNames=Hbut_1601;
OS Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5).
OC Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC Pyrodictiaceae; Hyperthermus.
OX NCBI_TaxID=415426;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5456 / JCM 9403 / PLM1-5;
RX PubMed=17350933; DOI=10.1155/2007/745987;
RA Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A.,
RA Awayez M., She Q., Garrett R.A., Klenk H.-P.;
RT "The genome of Hyperthermus butylicus: a sulfur-reducing, peptide
RT fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C.";
RL Archaea 2:127-135(2007).
CC -!- FUNCTION: Molecular chaperone capable of stabilizing a range of
CC proteins. Seems to fulfill an ATP-independent, HSP70-like function
CC in archaeal de novo protein folding. {ECO:0000255|HAMAP-
CC Rule:MF_00308}.
CC -!- SUBUNIT: Heterohexamer of two alpha and four beta subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00308}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00308}.
CC -!- SIMILARITY: Belongs to the prefoldin alpha subunit family.
CC {ECO:0000255|HAMAP-Rule:MF_00308}.
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DR EMBL; CP000493; ABM81420.1; -; Genomic_DNA.
DR RefSeq; WP_011822738.1; NC_008818.1.
DR ProteinModelPortal; A2BN59; -.
DR SMR; A2BN59; -.
DR STRING; 415426.Hbut_1601; -.
DR EnsemblBacteria; ABM81420; ABM81420; Hbut_1601.
DR GeneID; 4782502; -.
DR KEGG; hbu:Hbut_1601; -.
DR eggNOG; arCOG01341; Archaea.
DR eggNOG; COG1730; LUCA.
DR KO; K04797; -.
DR OrthoDB; POG093Z0IB3; -.
DR BioCyc; HBUT415426:GC56-1601-MONOMER; -.
DR Proteomes; UP000002593; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016272; C:prefoldin complex; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR HAMAP; MF_00308; PfdA; 1.
DR InterPro; IPR011599; PFD_alpha_archaea.
DR InterPro; IPR004127; Prefoldin_subunit_alpha.
DR Pfam; PF02996; Prefoldin; 1.
DR TIGRFAMs; TIGR00293; TIGR00293; 1.
PE 3: Inferred from homology;
KW Chaperone; Complete proteome; Cytoplasm; Reference proteome.
FT CHAIN 1 154 Prefoldin subunit alpha.
FT /FTId=PRO_0000322249.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 7 142 ihamap:PfdA [T]
FT MYHIT 23 140 ipfam:Prefoldin [T]
SQ SEQUENCE 154 AA; 16877 MW; 3914B0E02F1F4A04 CRC64;
MSQAGQSSRT ITLEEALEQL SLLESQLNQL QATIREIEVR IAQLTAVEDA LASLAEGAED
ALIPLDGRGT VLVPASIKKL ERILVHAGLN VFVEVDREKA LEYLRDEKAA LSKLLDAYSR
EYARLAQYYS ALRSAIESAL QAAPPQAKSQ QSQQ
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