ID A2BN25_HYPBU Unreviewed; 247 AA.
AC A2BN25;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 10-MAY-2017, entry version 52.
DE RecName: Full=Endonuclease V {ECO:0000256|HAMAP-Rule:MF_00801};
DE EC=3.1.21.7 {ECO:0000256|HAMAP-Rule:MF_00801};
DE AltName: Full=Deoxyinosine 3'endonuclease {ECO:0000256|HAMAP-Rule:MF_00801};
DE AltName: Full=Deoxyribonuclease V {ECO:0000256|HAMAP-Rule:MF_00801};
DE Short=DNase V {ECO:0000256|HAMAP-Rule:MF_00801};
GN Name=nfi {ECO:0000256|HAMAP-Rule:MF_00801};
GN OrderedLocusNames=Hbut_1565 {ECO:0000313|EMBL:ABM81386.1};
OS Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5).
OC Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC Pyrodictiaceae; Hyperthermus.
OX NCBI_TaxID=415426 {ECO:0000313|EMBL:ABM81386.1, ECO:0000313|Proteomes:UP000002593};
RN [1] {ECO:0000313|EMBL:ABM81386.1, ECO:0000313|Proteomes:UP000002593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5456 / JCM 9403 / PLM1-5
RC {ECO:0000313|Proteomes:UP000002593};
RX PubMed=17350933;
RA Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A.,
RA Awayez M., She Q., Garrett R.A., Klenk H.-P.;
RT "The genome of Hyperthermus butylicus: a sulfur-reducing, peptide
RT fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C.";
RL Archaea 2:127-135(2007).
CC -!- FUNCTION: DNA repair enzyme involved in the repair of deaminated
CC bases. Selectively cleaves double-stranded DNA at the second
CC phosphodiester bond 3' to a deoxyinosine leaving behind the intact
CC lesion on the nicked DNA. {ECO:0000256|HAMAP-Rule:MF_00801}.
CC -!- CATALYTIC ACTIVITY: Endonucleolytic cleavage at apurinic or
CC apyrimidinic sites to products with a 5'-phosphate.
CC {ECO:0000256|HAMAP-Rule:MF_00801}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00801};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00801}.
CC -!- SIMILARITY: Belongs to the endonuclease V family.
CC {ECO:0000256|HAMAP-Rule:MF_00801}.
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DR EMBL; CP000493; ABM81386.1; -; Genomic_DNA.
DR RefSeq; WP_011822704.1; NC_008818.1.
DR ProteinModelPortal; A2BN25; -.
DR STRING; 415426.Hbut_1565; -.
DR EnsemblBacteria; ABM81386; ABM81386; Hbut_1565.
DR GeneID; 4782943; -.
DR KEGG; hbu:Hbut_1565; -.
DR eggNOG; arCOG00929; Archaea.
DR eggNOG; COG1515; LUCA.
DR HOGENOM; HOG000229135; -.
DR KO; K05982; -.
DR OMA; HIGVVLK; -.
DR OrthoDB; POG093Z0CUB; -.
DR BioCyc; HBUT415426:GC56-1565-MONOMER; -.
DR Proteomes; UP000002593; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043737; F:deoxyribonuclease V activity; IEA:UniProtKB-HAMAP.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-HAMAP.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-HAMAP.
DR CDD; cd06559; Endonuclease_V; 1.
DR HAMAP; MF_00801; Endonuclease_5; 1.
DR InterPro; IPR007581; Endonuclease-V.
DR PANTHER; PTHR28511; PTHR28511; 1.
DR Pfam; PF04493; Endonuclease_5; 1.
PE 3: Inferred from homology;
KW Complete proteome {ECO:0000313|Proteomes:UP000002593};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00801};
KW DNA damage {ECO:0000256|HAMAP-Rule:MF_00801};
KW DNA repair {ECO:0000256|HAMAP-Rule:MF_00801};
KW Endonuclease {ECO:0000256|HAMAP-Rule:MF_00801,
KW ECO:0000313|EMBL:ABM81386.1};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_00801,
KW ECO:0000313|EMBL:ABM81386.1};
KW Magnesium {ECO:0000256|HAMAP-Rule:MF_00801};
KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_00801};
KW Nuclease {ECO:0000256|HAMAP-Rule:MF_00801,
KW ECO:0000313|EMBL:ABM81386.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002593}.
FT METAL 39 39 Magnesium. {ECO:0000256|HAMAP-
FT Rule:MF_00801}.
FT METAL 105 105 Magnesium. {ECO:0000256|HAMAP-
FT Rule:MF_00801}.
FT SITE 75 75 Interaction with target DNA.
FT {ECO:0000256|HAMAP-Rule:MF_00801}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 5 226 ihamap:Endonuclease_5 [T]
FT MYHIT 16 217 ipfam:Endonuclease_5 [T]
SQ SEQUENCE 247 AA; 27040 MW; B0577599C61FEEDA CRC64;
MTYSSVAKLI ELQKRLSRRI VSSLKPMDTA SIRRIVGLDA AYSKRYGGVA IAALTTRDGQ
LLTYSVALGE PPLQYIPGLL AFREAPLFYT ALRLLDSNYD LVVVDGHGIS HPRRAGIASH
IGIAIAKPSI GVAKKKLYGH EQIVSEDCKP PCIAGYVVDE DTGEKLAAIV RTGRSKKSRL
YVSPGAYTDL DSATTIVLEL LEARKTPLPA PTYHADRISK TIARQLDSGE LSPRSLKKRH
RTLLDYI
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