Entry euk:Q9VSE2_DROME

ID   Q9VSE2_DROME            Unreviewed;      1051 AA.
AC   Q9VSE2; Q6NP41;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   10-MAY-2017, entry version 144.
DE   SubName: Full=Mutagen-sensitive 301 {ECO:0000313|EMBL:AAF50481.1};
DE   SubName: Full=RE48845p {ECO:0000313|EMBL:AAR82756.2};
GN   Name=mus301 {ECO:0000313|EMBL:AAF50481.1,
GN   ECO:0000313|FlyBase:FBgn0002899};
GN   Synonyms=anon-WO0118547.354 {ECO:0000313|EMBL:AAF50481.1},
GN   Dmel\CG7972 {ECO:0000313|EMBL:AAF50481.1},
GN   mus(3)301 {ECO:0000313|EMBL:AAF50481.1},
GN   Mus301 {ECO:0000313|EMBL:AAF50481.1},
GN   spn-C {ECO:0000313|EMBL:AAF50481.1},
GN   SpnC {ECO:0000313|EMBL:AAF50481.1},
GN   spnC {ECO:0000313|EMBL:AAF50481.1};
GN   ORFNames=CG7972 {ECO:0000313|EMBL:AAF50481.1,
GN   ECO:0000313|FlyBase:FBgn0002899},
GN   Dmel_CG7972 {ECO:0000313|EMBL:AAF50481.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF50481.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AAF50481.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:AAF50481.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:AAF50481.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:AAF50481.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [5] {ECO:0000313|EMBL:AAF50481.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AAF50481.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:AAR82756.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Berkeley {ECO:0000313|EMBL:AAR82756.2};
RA   Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA   Park S., Wan K., Yu C., Celniker S.;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:AAF50481.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA   Svirskas R., Rubin G.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:AAF50481.1}
RP   NUCLEOTIDE SEQUENCE.
RG   Berkeley Drosophila Genome Project;
RA   Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA   Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E.,
RA   Yu C., Rubin G.;
RT   "Drosophila melanogaster release 4 sequence.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:AAF50481.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [11] {ECO:0000313|EMBL:AAF50481.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
RN   [12] {ECO:0000313|EMBL:AAF50481.1}
RP   NUCLEOTIDE SEQUENCE.
RG   FlyBase;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AE014296; AAF50481.1; -; Genomic_DNA.
DR   EMBL; BT011090; AAR82756.2; -; mRNA.
DR   RefSeq; NP_648178.1; NM_139921.4.
DR   UniGene; Dm.15493; -.
DR   IntAct; Q9VSE2; 4.
DR   STRING; 7227.FBpp0076412; -.
DR   EnsemblMetazoa; FBtr0076689; FBpp0076412; FBgn0002899.
DR   GeneID; 38905; -.
DR   KEGG; dme:Dmel_CG7972; -.
DR   UCSC; CG7972-RA; d. melanogaster.
DR   CTD; 38905; -.
DR   FlyBase; FBgn0002899; mus301.
DR   eggNOG; KOG0950; Eukaryota.
DR   eggNOG; COG1204; LUCA.
DR   GeneTree; ENSGT00640000091272; -.
DR   KO; K19178; -.
DR   OMA; FNSNERG; -.
DR   OrthoDB; EOG091G021D; -.
DR   GenomeRNAi; 38905; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0002899; -.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004004; F:ATP-dependent RNA helicase activity; IBA:GO_Central.
DR   GO; GO:0004386; F:helicase activity; ISS:FlyBase.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0016321; P:female meiosis chromosome segregation; IMP:FlyBase.
DR   GO; GO:0007294; P:germarium-derived oocyte fate determination; IMP:FlyBase.
DR   GO; GO:0008298; P:intracellular mRNA localization; IMP:FlyBase.
DR   GO; GO:0030717; P:karyosome formation; IMP:FlyBase.
DR   GO; GO:0048477; P:oogenesis; IGI:FlyBase.
DR   GO; GO:0009949; P:polarity specification of anterior/posterior axis; IMP:FlyBase.
DR   GO; GO:0009951; P:polarity specification of dorsal/ventral axis; IMP:FlyBase.
DR   GO; GO:0006417; P:regulation of translation; TAS:FlyBase.
DR   GO; GO:0010501; P:RNA secondary structure unwinding; IBA:GO_Central.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 3.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT   DOMAIN      274    446       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      497    689       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       260    455       ismart:DEXDc [T]
FT   MYHIT       496    643       ipfam:Helicase_C [T]
FT   MYHIT       274    446       iprf:HELICASE_ATP_BIND_1 [T]
FT   MYHIT       497    689       iprf:HELICASE_CTER [T]
FT   MYHIT       557    643       ismart:HELICc [T]
FT   MYHIT       274    429       ipfam:DEAD [T]
SQ   SEQUENCE   1051 AA;  117332 MW;  15B051F526844D8A CRC64;
     MANKHNLCKK RSLDLSEEST SESHAKRQCT ENLFWPEGED DDSFFSNAHL EDLLDGRKEE
     LFGTQATTST NKMTQSGSDD GLGLFADTSF PSAQSVPPNS ASKPDEASAP TDKHQIDLAD
     EENADKLFKK INLNDLSIAE MEDIFHGADD FSDPMVQNTQ LFLDAMTFKK PKTPEKLLAP
     LKDDSMSFIS KSVIEGLVQG TQYVTCEELK NQSLLDPVNW ETQAFADFEK NNQDIDKFPS
     KGEFYGLPDK VKKMILEHKG INSLYEWQDE CLNLPAIRQR KNLIYALPTS GGKTLVAEIL
     MLRELLCRER NVLFILPYVS IVQEKVSAMS PFAIDLDFIV EEYTAGKGKC PPQPRRKRRS
     LFIASIEKGA VLMDSLIDVQ RPHEIGLVVV DELHLIGEKG RGATLEAFLT KVMFLNANIQ
     IVGMSATIGN LSEISSFLNA DVYTRGFRPV ELKEYIKCGP DLLEINSAGQ TLEEIFVPSR
     SVEYNYSEAV KRADPDHLAG LISECAPEHC CLVFCPSRKN CENVALLLSR IVPKHKFFEH
     RRSEKLDLMD ALDKMCGILS PVLAKTLPYG IAYHHSGLTT DERKYIETAY RFGVVTVICC
     TSTLAAGVNL PAKRVIIRAP YVGQEFLTLC KYKQMVGRAG RAGLGEAGES ILIAQSKDNL
     LVGQMLFSPM DKALSSLDQN EAVGLQSLIL SVVGLNLAEC RRDLNRLVNS TLLSVQAKSL
     EVAVNEIVLR ILREMFKNKV LQLAEPQAKS KINSSDIITS QDVSQANRPA GDRRLLIGQS
     TPFKLTNIGR AAFKAGIDYK RANAIHKELK QAQQQLILTN YLHLLYLVVC FNSNERGDEL
     FPADASILFG VYTSLPLDSQ AMFKQLGFTE AHAARLFKTQ SVQGPLSLQL NRLYKVLILA
     DILNLLPIPS VASKYNVERG TLQHLISQST AAASAIVRLC EELEEFWCYK PLFERILHKM
     DRCGTFELEP LMELPAVKIN RARQLYAAGF QTIGDIARVR PSHLVQSLEH MPLRVATEIV
     SAAKIILMKK LDHLEEETEN LKDCLKTSDK N
//