Entry euk:Q6P7Y0_DANRE

ID   Q6P7Y0_DANRE            Unreviewed;       314 AA.
AC   Q6P7Y0;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   10-MAY-2017, entry version 97.
DE   SubName: Full=Ubiquitin-conjugating enzyme E2, J1 {ECO:0000313|Ensembl:ENSDARP00000043217};
DE   SubName: Full=Zgc:63554 {ECO:0000313|EMBL:AAH61451.1};
GN   Name=ube2j1 {ECO:0000313|Ensembl:ENSDARP00000043217,
GN   ECO:0000313|ZFIN:ZDB-GENE-040426-2853};
GN   Synonyms=zgc:63554 {ECO:0000313|EMBL:AAH61451.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH61451.1};
RN   [1] {ECO:0000313|EMBL:AAH61451.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB {ECO:0000313|EMBL:AAH61451.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:AAH61451.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000043217}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000043217};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000043217, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000043217,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
CC       {ECO:0000256|PROSITE-ProRule:PRU00388}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BX248418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC061451; AAH61451.1; -; mRNA.
DR   RefSeq; NP_999932.1; NM_214767.1.
DR   UniGene; Dr.82326; -.
DR   STRING; 7955.ENSDARP00000043217; -.
DR   Ensembl; ENSDART00000043218; ENSDARP00000043217; ENSDARG00000033489.
DR   GeneID; 406794; -.
DR   KEGG; dre:406794; -.
DR   CTD; 51465; -.
DR   ZFIN; ZDB-GENE-040426-2853; ube2j1.
DR   eggNOG; KOG0428; Eukaryota.
DR   eggNOG; COG5078; LUCA.
DR   GeneTree; ENSGT00530000063379; -.
DR   HOGENOM; HOG000167871; -.
DR   HOVERGEN; HBG058959; -.
DR   KO; K10578; -.
DR   OMA; DFCCEMC; -.
DR   OrthoDB; EOG091G0JU3; -.
DR   TreeFam; TF101124; -.
DR   Proteomes; UP000000437; Chromosome 20.
DR   Bgee; ENSDARG00000033489; -.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR   CDD; cd00195; UBCc; 1.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   Pfam; PF00179; UQ_con; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
DR   PROSITE; PS50127; UBIQUITIN_CONJUGAT_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:Q6P7Y0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    281    299       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       13    119       UBIQUITIN_CONJUGAT_2.
FT                                {ECO:0000259|PROSITE:PS50127}.
FT   ACT_SITE     91     91       Glycyl thioester intermediate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00388}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT        13    119       iprf:UBIQUITIN_CONJUGAT_2 [T]
FT   MYHIT        14    120       ipfam:UQ_con [T]
SQ   SEQUENCE   314 AA;  34276 MW;  B24EC02379420DCC CRC64;
     MESKYNLKSP AVKRLMKEAA ELRDPTEHYH AQPLEDNLFE WHFSVRGPPD SDFDGGVYHG
     RIVLPPEYPM KPPSIILLTP NGRFEVGKKI CLSISGHHPE TWQPSWSIRT ALIAIIGFMP
     TKGEGAIGSL DYTPEERKAL AKKSQDFCCE ACSSCMRSAL LPLSPDSDLR PADPQRLAQQ
     INFKAESSSS AADSSSSSSA AAEVFSNTSE SSETADQDTE DTSAAEQTES SSVAPQTSAE
     DPSVSAAPSP RQRRSQNQSP RSPVFPASPA PPHLPQDSSR TGSAILIVLL TLALAALIFR
     RIYLAHEYKF DYEL
//